Role of ROS in AB42 mediated cell surface p-selectin expression and actin polymerization
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Date
2013
Authors
Tsoy, A.
Askarova, Sholpan
Shalakhmetova, T.
Umbayev, B.
Adambekov, S.
Zhumadilov, Z.
Journal Title
Journal ISSN
Volume Title
Publisher
Nazarbayev University
Abstract
The results of our study have indicated that Aβ42 induces expression of P-selectin on the surface of bEnd3 cells and promotes actin polymerization in a time dependent manner, and all these events correlate with ROS generation. The rapid, posttranslational cell signaling response mediated by ROS, may well represent an important physiological trigger of the micro vascular inflammatory response in AD and requires further investigations.
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Keywords
first research week, cells, ROS generation