THE DOSE-DEPENDENT EFFECT OF ANTI-MICROTUBULE DRUGS ON CANCER CELLS
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Date
2021-05-08
Authors
Bekbayev, Sultan
Journal Title
Journal ISSN
Volume Title
Publisher
Nazarbayev University School of Sciences and Humanities
Abstract
Drugs inhibiting microtubule dynamics are widely used in the treatment of various
types of cancer. However, the molecular mechanisms are not fully investigated. The aim of
this thesis is to study drug- and dose-dependent effect of the inhibitors of microtubule drugs
on the cancer cells by treating them with the wide range of concentrations anti-microtubule
drugs and observing the fate of mitotic cells directly under microscope. This will allow us to
obtain systematic knowledge on the threshold concentrations of anti-microtubule drugs, which
will open new prospects in disentangling molecular mechanisms of the action of these drugs.
In this work two distinct effects of anti-microtubule drugs were investigated, and they
were quantified with introducing the concept of minimal mitostatic concentration, and novel
second threshold concentration.
Description
Keywords
cancer, cancer cells, Type of access: Open Access, drugs inhibiting microtubule dynamics, minimal mitostatic concentration
Citation
Bekbayev, S. (2021). The dose-dependent effect of anti-microtubule drugs on cancer cells (Unpublished mater`s thesis). Nazarbayev University, Nur-Sultan, Kazakhstan