COGNITIVE FUNCTION DETERMINANTS IN OLDER PERSONS IN URBAN AND RURAL POPULATION IN THE NUR-SULTAN REGION, KAZAKHSTAN: CROSS-SECTIONAL STUDY
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Date
2020
Authors
Supiyev, Adil
Kossumov, Alibek
Journal Title
Journal ISSN
Volume Title
Publisher
International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana
Abstract
Objective: The data on the cognitive function and its determinants in older population in Central Asia
is limited. The objective of the present study was to assess the cognitive function and its determinants in
the population of Nur-Sultan city and adjacent rural area in Kazakhstan.
Methods: We implemented a cross-sectional study of urban and rural population samples (the state
capital Nur-Sultan and Akmol village). Men and women aged 50–74 years were examined; a total of 954
adults participated in this study with response rate of 59%. One of the major components of cognitive
function - verbal memory was assessed for this analysis using a word recall task consisting of 10 common
nouns, administered over three consecutive 1-min trials. Total number of words correctly recalled
for each trial was summed with an overall score of 30 at maximum. The examination also included the
standardized protocol with a structured questionnaire, objective examination and collection of blood
samples.
Results: After controlling for age and sex the presence of cardiometabolic risk factors (excluding BMI),
region, ethnicity, alcohol consumption, education levels and selected socioeconomic factors were all
significantly associated with cognitive function. Women, less deprived and higher educated participants,
and urban residents had significantly less decline in memory. Similar to other studies, higher cholesterol
levels were strongly associated with cognitive decline.
Conclusions: The associations of cognitive function and its determinants were as expected, and there
were some specific associations with socio-demographic characteristics. The pronounced socio-demographic
particularly regional differences suggest that preventive strategies may target population groups
at higher risk for cognitive decline.
Description
Keywords
Socio-economic determinants, cognitive function, Research Subject Categories::MEDICINE, Kazakhstan