Correlation of Serum Biomarkers With the Risk Factors of Colorectal Cancer
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Date
2020
Authors
Akhmaltdinova, L.L.
Avdienko, O.V.
Ibraeva, A.S.
Zhumaliyeva, V.A.
Tauesheva, Z.B.
Journal Title
Journal ISSN
Volume Title
Publisher
International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana
Abstract
Introduction: The search of effective serum biomarkers to diagnose, forecast and evaluate the severity
of cancer is a hard and so far unsolved problem. Studying their dynamics, limitations as well as their
interaction with clinical signs could help understand their points of application and their effective use.
Methods: a group of patients first time diagnosed with colorectal cancer took part in the investigation
(n=100). The age: (Ме [25%;75%]) 66.6 years old [62;72]; 45% men and 55% women. A standard clinical
examination and patient reported outcomes to reveal the risk factors were performed. Biomarker blood
test was done prior to surgery. To study serum biomarkers, 24 Milliplex Human Circulation Biomarker
Set was used. PD-L1was determined using Human ProcartaPlex™ Kit. Oncomarker CA 72-4 was identified
using ELISA kit by Xema. For Statistic processing Gamma Correlition was taken. It was found that BMI
correlated with the contents of Afp (gamma correlation) (0.41), CEA (-0.25), He4 (-0.39), SFas (0.32) and
PDL-1(-0.46). A regular polyvitamin ingestion correlated with PDL-1(0.40) and IL-6 (0.35). Regular NSAIDs
ingestion related to IL-6 level (0.30). CA125 (0.44), Leptin (-0.55), MIF (0.44) and OPN (0.59) were found
to correlate with smoking, and CA19-9 (0.66), IL-6(0.52), MIF (0.53), TNF (0,49) and VEGF (0,53) - with the
number of cigarettes smoked. As to the severity and the localization, the following correlations were
found: AFP was related to the tumour localization C18.4 (0.8) and the accompanying diverticulosis (0.68)
and the presence of metastases (0.62). CA19-9 correlated with С18.2localization. CEA and IL-8 were found
to correlate with КРР (0.33 and 0.34 correspondingly), and with the size of the tumour (0.29 and 0.31).
IL-6, MIF and TGF markers were linked with the presence of metastases (0.84;0.66; 0.57). CA15-3 was
found to correlate with diverticulosis (0.75). Speaking about separate markers correlation, the strongest
correlations were revealed between sFasL and TNF (0.41); TGF and FGF (0.49). Thus, on the one hand, the
diversity of factors influencing the character of serum biomarkers in patients with oncological disease
interfere background values, but on the other, can serve a basis for a complex diagnostic panel.
Description
Keywords
biomarkers, serum, CEA, colorectal cancer, Research Subject Categories::MEDICINE