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Browsing Abstracts by Title

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  • DELIVERY OF MONOCLONAL ANTIBODIES FROM MICROENCAPSULATED CELLS 
    Ashimova, A.; Hortelano, G. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Monospecific immunoglobulins (monoclonal antibodies, MAb) of therapeutic interest have received significant attention since their development by Milstein and Kohler in 1975. The exquisite specificity of MAb, or the ability ...
  • DETERMINATION OF ANTIBACTERIAL SENSITIVITY OF BACTEROIDES FRAGILIS ISOLATED FROM INTRAABDOMINAL INFECTIONS 
    Kozhakhmetova, S.; Zholdybayeva, E.; Atavliyeva, S.; Tarlykov, P.; Mukhtarova, K.; Syzdykov, T.; Khasenov, R.; Ramankulov, E. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Introduction: Modern intra-abdominal infections are characterized by rapidly growing antibiotic resistance. Gram-negative bacillus B.fragilis is one of the dominating anaerobic pathogens. Thus this research aims to study ...
  • DEVELOPMENT OF COSMETIC CREAM BASED ON THE HORSE-PLACENTA 
    Saliev, T.; Fakhradiyev, I.; Perfilyeva, Y.; Ostapchuk, Y.; Kali, A.; Abdolla, N.; Tleulieva, R. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Modern cosmetology possesses a huge arsenal of tools and methods for the prevention and treatment of various aesthetic problems. There is a range of medical and cosmetic products consisting of biologically active agents ...
  • DRUG RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS CLINICAL ISOLATES FROM NEW TB CASES IN KAZAKHSTAN 
    Kozhamkulov, U.; Akhmetova, A.; Rakhimova, S.; Daniyarov, A.; Molkenov, A.; Bismilda, V.; Chingissova, L.; Kairov, U.; Akilzhanova, A. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Introduction: Nowadays and worldwide, TB is one of the top 10 causes of death and the leading cause from a single infectious agent. The global incidence of drug-susceptible TB, multidrug-resistant (MDR) and extensively ...
  • EFFECT OF MARE’S MILK PREBIOTIC SUPPLEMENTATION ON THE GUT MICROBIOME AND THE IMMUNE SYSTEM DURING AND AFTER ANTIBIOTIC THERAPY 
    Nurgaziyev, M.; Aitenov, Y.; Khassenbekova, Zh.; Akpanova, S.; Rysbekov, K.; Kozhakhmetov, S.; Nurgozhina, A.; Sergazy, Sh.; Chulenbayeva, L.; Ospanova, Zh.; Tuyakova, A.; Mukhambetganov, N.; Sattybayeva, R.; Urazova, S.; Galymgozhina, N.; Gulyaev, A.; Kushugulova, A. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Antibiotic treatment can severely affect the gut microbiome with short-term and long-term consequences. Probiotic and prebiotic supplements are widely prescribed to modulate the composition and function of the human gut ...
  • THE EFFECTS OF PRECONDITIONED MESENCHYMAL STEM CELLS ON GASTRIC ULCER REGENERATION IN MICE 
    Zhunusova, M.S. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Introduction: During the last decade, preconditioned mesenchymal stem cells (MSCs) have gained much attention in the field of cell therapy due to their capacity to differentiate into different cell types and to promote ...
  • ENGINEERING CHEMOKINE-BASED CCR5 BLOCKERS TO TACKLE INFECTIOUS AND INFLAMMATORY DISEASES 
    Vangelista, Luca (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    The C-C chemokine receptor type 5, CCR5, is expressed on various cell types and is involved in a large number of pathophysiological conditions. In recent years, CCR5 gained a huge attention, as it was found to play a ...
  • ETIOLOGICAL STRUCTURE OF ACUTE BRONCHIOLITIS IN YOUNG CHILDREN 
    Turdalina, B.R.; Bayesheva, D.A.; Seydullaeva, A.Zh.; Omarova, A.K.; Esimkhanova, G.O.; Zhumabek, P. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Introduction: Bronchiolitis is most common in children under the age of 9 months in (90% of cases). Every year, 150 million cases of bronchiolitis are recorded in the world, 7-13% of which require inpatient treatment and ...
  • EVALUATION OF CYTOTOXICITY OF ORGANOSILICA NANOPARTICLES 
    Zhaisanbayeva, B. A.; Mun, E. A.; Vorobyev, I. A.; Hortelano, G.; Khutoryanskiy, V. V. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Over the past few decades, nanoparticles have been attracting attention of researches in chemical, biomedical, pharmaceutical sciences, due to their unique physicochemical properties. This includes small size, large ...
  • GENETIC VARIANTS, METABOLOME, AND GUT MICROBIOME BIOMARKERS FOR OBESITY AND AGING IN RANDOMLY SELECTED KAZAKH INDIVIDUALS 
    Akilzhanova, Ainur; Rakhimova, Saule; Kozhamkulov, Ulan; Kairov, Ulykbek; Kushugulova, Almagul R.; Terwilliger, Joseph; Lee, Joseph (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Objective: Metabolic syndrome (MS) is a cluster of inter-related and heritable metabolic traits, which collectively impart unsurpassed risk for atherosclerotic cardiovascular disease and type 2diabetes. Considerable work ...
  • GENOTYPING OF MYCOBACTERIUM TUBERCULOSIS ISOLATES AMONG RECURRENT CASES OF TUBERCULOSIS IN KAZAKHSTAN 
    Akhmetova, A.; Akilzhanova, A.; Toksanbaeva, B.; Bismilda, V.; Chingissova, L.; Kozhamkulov, U. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Introduction: Tuberculosis still remains one of the major health problems in Kazakhstan. According to the World Health Organization data (2018), Kazakhstan is on the list of 30 countries with high rates of multidrug ...
  • GUT MICROBIOME ALTERATIONS IN SENIORS SUFFERING FROM ALZHEIMER’S DISEASE 
    Askarova, Sholpan; Kaiyrlykyzy, Aiym; Kozhakhmetov, Samat S.; Nurgaziyev, Madiyar; Kushugulova, Almagul R. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Introduction: One of the important factors influencing human health and attracting increasing attention of scientists during the last two decades is gut microbiome. It has been demonstrated that the links exist between ...
  • HEREDITARY DISEASES AND CONGENITAL MALFORMATIONS REGISTRATION AND MONITORING INFORMATION SYSTEM 
    Nazarova, L.; Tolegen, N.; Bayanova, M. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Introduction. Database on hereditary diseases is one of the main tasks of healthcare. Register of hereditary pathology allows to assess accurately the frequency of childbirths with various hereditary diseases and congenital ...
  • IDENTIFICATION OF KAZAKH SPECIFIC GENOMIC VARIANTS USING COMPARATIVE GENOMICS ANALYSIS 
    Molkenov, A.; Daniyarov, A.; Sharip, A.; Seisenova, A.; Karabayev, D.; Kairov, U. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Introduction: The modern development of high-performance genomic technologies opens up new possibilities for studying the human genome. Large-scale genomic research generates huge amounts of data, the active development ...
  • ISOLATION FROM THE KAZAKH TRADITIONAL FOOD PRODUCTS OF A NEW STRAIN OF LACTIC ACID BACTERIA PRODUCING THE HUMAN PLASMINOGEN RECEPTOR 
    Shaikhin, S.; Abitayeva, G.; Abilhadirov, A.; Dossova, A.; Pirmanova, A.; Tynybaeva, I. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Lactobacillus bacteria are one of the most important groups of the human intestinal microbiota that promote health. Adhesion to host tissues represents a crucial early step in the colonization process of either pathogens ...
  • ISOLATION OF NATURAL REPRESENTATIVES OF CARP LACTOFLORA TO CREATE PATHOGEN CONTROL AGENTS THAT CAN BE ALTERNATIVE TO ANTIBIOTICS 
    Urazova, M.; Zakarya, K.; Sarmurzina, Z.; Bissenova, G.; Abitayeva, G.; Shevtsov, A.; Tekebayeva, Zh.; Tynybayeva, I.; Abzhalelov, A. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Currently, the microbiome of commercial fish species is being actively studied. In reviews, mainly based on metagenome analysis features and formation of intestinal microflora of various fish species of North America, ...
  • LAUNCH OF Q-SYMPHONY BIOINFORMATICS COMPUTING SYSTEM: A HIGH-PERFORMANCE CLUSTER FOR ANALYSIS OF LARGE-SCALE GENOMIC DATASETS 
    Molkenov, A.; Daniyarov, A.; Sharip, A.; Seisenova, A.; Karabayev, D.; Kairov, U. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Introduction: One whole human genome, provided by next generation sequencing platforms, in raw format takes 20 to 50 GB. In the course of bioinformatics analysis and data analysis, the data volume increases to 300-500 ...
  • Measures of Reducing the Burden of Health Care Costs by Rational Usage of Laboratory Tests 
    Marchenko, Y.; Akhmetove, R. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Introduction: Every year manufacturers offer new tests, postulating that it will improve the outcomes of treatment. That results that laboratories have to face an increasing workload combined with a reduction of resources. ...
  • META-ANALYSIS OF CANCER TRANSCRIPTOMES USING INDEPENDENT COMPONENT ANALYSIS 
    Seisenova, A.; Sharip, A.; Molkenov, A.; Daniyarov, A.; Karabayev, D.; Kairov, U. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Introduction: Independent Component Analysis (ICA) is a matrix factorization method for data dimension reduction. ICA has been widely applied for the analysis of transcriptomic data for blind separation of biological, ...
  • Molecular Genetic Approaches in Diagnosis of Duschenne/ Becker Muscular Dystrophy 
    Bayanova, M.; Uahit, R.; Tolegen, N.; Nazarova, L.; Abilkhadirova, A.; Khamzina, A.; Nauryzbaeva, A.; Jaxybayeva, A. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Introduction: Duchenne/Becker muscular dystrophy (DMD/BMD) is inherited X-linked disease with a frequency of 1: 3,500 newborn males. Deletions and duplications in the DMD gene are errors of reading frameshift and premature ...