Epigenetic reprogramming of cancer cells under embryonic microenvironment
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Date
2014
Authors
Mu, X.
Sultankulov, B.
Agarwal, R.
Mahjoub, A.
Schott, T.
Greco, N.
Huard, J.
Weiss, K.
Journal Title
Journal ISSN
Volume Title
Publisher
Nazarbayev University
Abstract
The idea of epigenetic reprogramming of cancer cells by an embryonic microenvironment
possesses potential interest from the prospect of both basic science and potential therapeutic strategies.
Chick embryo extract (CEE) has been used for the successful expansion of many specific stem cells
and has demonstrated the ability to facilitate DNA demethylation. The current study was conducted to
compare the status of DNA methylation in highly metastatic and less metastatic osteosarcoma cells and
to investigate whether CEE may affect the epigenetic regulation of tumor suppressor genes and thus
change the metastatic phenotypes of highly metastatic osteosarcoma cells.
Description
Keywords
epigenetic reprogramming, embryonic microenvironment, osteosarcoma cells, cell apoptosis, genes