Whole genome sequencing of mycobacterium tuberculosis in Kazakhstan: first sequence results of two clinical isolates
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Date
2014
Authors
Molkenov, A.
Kairov, U.
Kozhamkulov, U.
Rakhimova, S.
Askapuli, A.
Zhabagin, M.
Abilova, Zh.
Akhmetova, A.
Yerezhepov, D.
Abilmazhinova, A.
Journal Title
Journal ISSN
Volume Title
Publisher
Nazarbayev University
Abstract
The project is aimed to create the prerequisites for a personalized approach to the diagnosis
and treatment of tuberculosis (TB) by identifying and comparing the whole genome sequences of
M.tuberculosis strains isolated in Kazakhstan. Analysis for whole genome sequences obtained using the
next generation sequencing technology will clarify the factors cause of the formation of highly virulent
strains of M.tuberculosis, the evolution of local strains, and genetic markers of drug resistance.
Description
Keywords
genome sequences, tuberculosis, genetic markers, strains