Aberrant repair initiated by the adenine-DNA glycosylase does not play a role in UV-induced mutagenesis in Escherichia coli
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Date
2018-12-15
Authors
Zutterling, Caroline
Mursalimov, Aibek
alhaoui, Ibtissam
Koshenov, Zhanat
Akishev, Zhiger
Bissenbaev, Amangeldy K.
Mazon, Gerard
Geacintov, Nicolas E.
Gasparutto, Didier
Groisman, Regina
Journal Title
Journal ISSN
Volume Title
Publisher
BIOCHEMISTRY, BIOPHYSICS AND MOLECULAR BIOLOGY
Abstract
DNA repair is essential to counteract damage to DNA induced by
endo- and exogenous factors, to maintain genome stability. However, challenges to
the faithful discrimination between damaged and non-damaged DNA strands do
exist, such as mismatched pairs between two regular bases resulting from
spontaneous deamination of 5-methylcytosine or DNA polymerase errors during
replication. To counteract these mutagenic threats to genome stability, cells evolved
the mismatch-specific DNA glycosylases that can recognize and remove regular
DNA bases in the mismatched DNA duplexes. The Escherichia coli adenine-DNA
glycosylase (MutY/MicA) protects cells against oxidative stress-induced mutagenesis
by removing adenine which is mispaired with 7,8-dihydro-8-oxoguanine (8oxoG)
in the base excision repair pathway....
Description
Keywords
Nucleotide excision repair
Citation
Zutterling C, Mursalimov A, Talhaoui I, Koshenov Z, Akishev Z, Bissenbaev AK, Mazon G, Geacintov NE, Gasparutto D, Groisman R, Zharkov DO, Matkarimov BT, Saparbaev M. 2018. Aberrant repair initiated by the adenine-DNA glycosylase does not play a role in UV-induced mutagenesis in Escherichia coli. PeerJ 6:e6029 https://doi.org/10.7717/peerj.6029