Deletion of HP1γ in cardiac myocytes afects H4K20me3 levels but does not impact cardiac growth
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Date
2018-04-18
Authors
El‑Nachef, Danny
Fang, Chen
Kajimoto, Hidemi
Brown, Jeremy P.
Singh, Prim B.
MacLellan, W. Robb
Journal Title
Journal ISSN
Volume Title
Publisher
Epigenetics Chromatin
Abstract
Heterochromatin, which is formed when tri-methyl lysine 9 of histone H3 (H3K9me3) is bound by heterochromatin 1 proteins (HP1s), plays an important role in differentiation and senescence by silencing cell cycle genes. Cardiac myocytes (CMs) accumulate heterochromatin during differentiation and demethylation of H3K9me3 inhibits cell cycle gene silencing and cell cycle exit in CMs; however, it is unclear if this process is mediated by HP1s. In this study, we created a conditional CM-specific HP1 gamma (HP1γ) knockout (KO) mouse model and tested whether HP1γ is required for cell cycle gene silencing and cardiac growth....
Description
Keywords
cardiac myocytes, cell cycle, conditional knockout, gene expression
Citation
Oyama K., El-Nachef D., Fang C., Kajimoto H., Brown JP., Singh PB., MacLellan WR. (2018) Deletion of HP1γ in cardiac myocytes affects H4K20me3 levels but does not impact cardiac growth.Epigenetics Chromatin.