Role of HSC70 protein in maintenance of endoplasmic reticulum CA2+ homeostasis
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Date
2014
Authors
Khamzina, Y.
Nauryzbayeva, A.
Gilman, C.
Journal Title
Journal ISSN
Volume Title
Publisher
Nazarbayev University
Abstract
Intracellular calcium homeostasis is disrupted in many neuronal diseases and traumatic
brain injuries resulting in endoplasmic reticulum (ER) stress [1]. ER stress and intracellular calcium
homeostasis is a hub of signaling mechanisms that determine whether injured neurons will live or die.
With survivable injuries neurons seek to restore normal function by several mechanisms including the
upregulation of chaperones [2]. Hsc70 (aka Hsp73 and HSPA8) is one of such proteins, which is found
to be highly concentrated in neurons. Unlike other chaperones in the HSP family Hsc70 is constitutively
expressed and interacts with both cell cycle and apoptosis regulating proteins [3]. Therefore, we tested
the hypothesis that Hsc70 regulates neural stem cell fate in response to changes intracellular calcium
homeostasis. Currently little is known about the function of this novel chaperone or about the role of ER
calcium homeostasis in neural stem cell fate determination and this work is the first to investigate this
topic.
Description
Keywords
intracellular, calcium, homeostasis, neuronal, brain, endoplasmic, reticulum, injuries, apoptosis