Anticancer Effects and uses of Melatonin A Review
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Date
2015-08
Authors
Mektepbayeva, Damel
Alibek, Kenneth
Atinbayeva, N.
Irving, S
Zhaisanbayeva, B
Mussurova, S
Mussakhan, S
Journal Title
Journal ISSN
Volume Title
Publisher
Austin Journal of Cancer and Clinical Research
Abstract
Melatonin (N-acetyl-5-methoxytryptamine, MLT) is a naturally occurring
hormone secreted by the pineal gland. Clinical evidence suggests that MLT
may have a possible role in the treatment of cancer, where MLT presents
many oncostatic properties in a wide variety of tumors, utilizing multiple and
converging mechanisms. It is a potent anti-oxidative agent; its circadian
rhythm-regulating properties are crucial for orchestrating patterns of hormone
secretion, the imbalance of which is implicated in a wide range of hormonedependent
cancers of the reproductive organs. Recent advances in cancer
treatment can offer therapeutic alternatives that could reduce the severity of
unwanted side effects. Several observational studies have demonstrated a
relationship between long-term disruption of circadian rhythm with decreased
MLT secretion and increased cancer risk, whilst clinical evidence supports the
possible benefits from MLT on the survival in patients with a range of cancers.
This review will address some of the multiple anticancer properties of MLT,
with a particular focus on the mechanisms counteracting tumor occurrence,
growth, and development. Recent research into the oncostatic effects of MLT
and the mechanisms of action explaining its efficiency for tumor regulation are
summarized in this review and suggestions for the therapeutic use of MLT will
be presented.
Description
Keywords
Melatonin, Cancer treatment, Anti-oxidant, Anti-proliferative, Immunoenhancer
Citation
Mektepbayeva Damel, Alibek Kenneth, Atinbayeva N., Irving S., Zhaisanbayeva B., Mussurova S., Mussakhan S. Anticancer Effects and uses of Melatonin A Review. 2015. Austin Journal of Cancer and Clinical Research