Genotyping Of M. Tuberculosis Clinical Isolates From New Cases Of Tuberculosis In Kazakhstan

Abstract

Tuberculosis (TB) remains a major health problem in Kazakhstan. Despite of that the rates of TB disease and mortality decreased from 58,5/100000 and 4,1/100000 in 2015 to 52,7/100000 and 3,4/100000 in 2016 respectively, the rate of multidrug-resistant TB (MDR-TB) increased from 12,2/100000 in 2014 to 13,5/100000 in 2015 [1]; MDR strains associated with resistance to the main two first line anti-TB drugs – isoniazid and rifampicin are the most dangerous. 27 countries relate to high MDR-TB burden countries, 15 of them in the European region, including Kazakhstan [2]; Methods of genotyping of M. tuberculosis play important role in TB infection control. There are more than 10 methods of genotyping, MIRU-VNTR is one of the widely used method in the world.