Removal of low and middle molecular weight toxins by activated carbon materials
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Date
2016-05
Authors
Akhmetova, A.
Howell, C.
Jandosov, J.
Baimenov, A.
Mansurov, Z.
Nurgozhin, T.
Mikhalovsky, S.
Journal Title
Journal ISSN
Volume Title
Publisher
National Laboratory Astana, NAZARBAYEV UNIVERSITY
Abstract
Haemoperfusion (HP), or blood purification via adsorption, has been introduced
almost at the same time as haemodialysis in 1960s. HP compared to dialysis does not introduce
any substances into the body and only removes the target molecules. Here, we research
properties of activated carbon (AC) materials for HP purposes, which can efficiently adsorb
substances in a broad range of molecular weights. Removing these substances individually,
e.g., by selective antibodies is prohibitively expensive and inefficient due to their short life-time
in blood circulation. And, dialysis and ultrafiltration are unable to remove these low and middle
molecular weight (LMW, MMW) substances efficiently. Here, we assess adsorption of uremic
toxins: p-cresyl sulfate, indoxyl sulfate, and urea.
Description
Keywords
activated carbon, hemoperfusion, toxin removal
Citation
A. Akhmetova, C. Howell, J. Jandosov, A. Baimenov, Z. Mansurov, T. Nurgozhin, and S. Mikhalovsky. 2016. Removal of low and middle molecular weight toxins by activated carbon materials. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1550