Elevated levels of plasma collagen priple helix repeat-containing (CTHRC1) protein correlates with increased granul ocytopoiesis and higher rheumatoid arthritis disease severity score
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Date
2016-05
Authors
Myngbay, A.
Bexeitov, Y.
Adilbayeva, A.
Yevstratenko, B. P.
Aitzhanova, R. M.
Otarbayev, N. K.
Adarichev, V.A.
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Abstract
Monitoring and suppressing activity of the pathological granulating pannus
tissue is essential for Rheumatoid Arthritis (RA) management. Synovial joints pain and tissue
destruction is a derivative of the pannus activity. In a mouse model for RAwe found CTHRC1,
a secreted and circulating protein, to be inducible in arthritis and correlated with the disease
severity. We performed a clinical investigation to ascertain the role of CTHRC1 in the progression
of the disease.
Description
Keywords
Rheumatoid Arthritis
Citation
A. Myngbay, Y. Bexeitov, A. Adilbayeva, B. P. Yevstratenko, R. M. Aitzhanova, N. K. Otarbayev, and V.A. Adarichev. 2016. Elevated levels of plasma collagen priple helix repeat-containing (CTHRC1) protein correlates with increased granul ocytopoiesis and higher rheumatoid arthritis disease severity score. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1521