A targeted sequencing reveal overlapping pattern of genetic variants in patients with cardiomyopathy with cardiac arrhythmias in Kazakhstan
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Date
2016-05
Authors
Akilzhanova, A.
Guelly, Ch.
Abilova, Zh.
Rakhimova, S.
Akhmetova, A.
Kairov, U.
Nuralinov, O.
Rashbayeva, G.
Trajanoski, S.
Zhumadilov, Zh.
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Abstract
Ventricular tachycardia (VT) is a common symptom in cardiac disorders of
different etiology. Abnormalities of ion channels are attributed to mutations in the genes
encoding the channel protein and cause altered function of channels, which can predispose to
arrhythmias. Due to the high incidence of cardiovascular disorders in Kazakhstan, we enrolled a
study cohort of 95 patients of different clinical phenotypes of cardiomyopathies, including DCM,
idiopathic VT but also patients with myocardial infarction as a consequence of coronary heart
disease. The common denominator among the three main groups was the occurrence of severe
episodes of VT in all patients. Using targeted resequencing, we investigated 96 cardiomyopathy
associated candidate-genes in this cohort with the aim to detect rare and common variations in
these genes associated with VT molecular basis
Description
Keywords
targeted sequencing, cardiac arrhythmias, HaloPlex cardiopanel
Citation
Akilzhanova, A., Guelly, Ch., Abilova, Zh., Rakhimova, S., Akhmetova, A., Kairov, U., Nuralinov, O., Rashbayeva, G., Trajanoski, S., Zhumadilov, Zh., Bebosynova, M. 2016. A targeted sequencing reveal overlapping pattern of genetic variants in patients with cardiomyopathy with cardiac arrhythmias in Kazakhstan. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1495