Abstract:
Targeted delivery of pharmaceutical agents to
the brain using magnetic nanoparticles (MNPs) is an
efficient technique to transport molecules to disease
locations. MNPs can cross the blood–brain barrier (BBB)
and can be concentrated at a specific location in the brain
using non-invasive electromagnetic forces. The proposed
EMA consists of two coil-core system. The cores are
added in the center of each coil to concentrate the flux in
the region of interest. The EMA can enhance the gradient
field 10 times compared to only coil system and generate
the maximum magnetic field of 160 mT and 5.6 T/m. A
12-kW direct-current power supply was used to generate
sufficient magnetic forces on the MNPs by regulating the
input currents of the coils. Effective guidance of MNPs is
demonstrated via simulations and experiments using
800-nm-diameter MNPs in a Y-shaped channel. The
developed EMA system has high potentials to increase
BBB crossing of MNPs for efficient drug targeting to
brain regions