Functionalized Magnetic Force Enhances Magnetic Nanoparticle Guidance: From Simulation to Crossing of the Blood-Brain Barrier in vivo
Loading...
Date
2016
Authors
Do, Ton Duc
Amin, Faiz Ul
Noh, Yeongil
Kim, Myeong Ok
Yoon, Jungwon
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
In recent studies, we introduced the concept of functionalized magnetic force as a method to prevent nanoparticles from sticking to
vessel walls caused by extensive simulation and in vitro experiments involving a Y-shaped channel. In this study, we further
investigated the effectiveness of the functionalized magnetic force with a realistic 3D vessel through simulations. For the simulations,
we considered a more realistic continuous injection of particles with different magnetic forces and frequencies. Based on the results
from our simulation studies, we performed in vivo mice experiments to evaluate the effectiveness of using a functionalized magnetic
force to aid magnetic nanoparticles (MNPs) in crossing the blood-brain barrier (BBB). To implement the functionalized magnetic
force, we developed an electromagnetic actuator regulated by a programmable direct current (DC) power supply. Our results indicate
that a functionalized magnetic field can effectively prevent MNPs from sticking, and also guide them across the BBB. We used 770-nm
fluorescent carboxyl MNPs in this study. Following intravenous administration of MNPs into mice, we applied an external magnetic
field (EMF) to mediate transport of the MNPs across the BBB and into the brain. Furthermore, we evaluated the differential effects of
functionalized magnetic fields (0.25, 0.5, and 1 Hz) and constant magnetic fields on the transport of MNPs across the BBB. Our results
showed that a functionalized magnetic field is more effective than a constant magnetic field in the transport and uptake of MNPs
across the BBB in mice. Specifically, applying a functionalized magnetic field with a 3 A current and 0.5 Hz frequency mediated the
greatest transport and uptake of MNPs across the BBB in mice
Description
Keywords
Blood-brain barrier, In vivo experiment, Mice, Targeted drug delivery, Electromagnetic actuation system, Simulation
Citation
Ton Duc Do, Faiz Ul Amin, Yeongil Noh, Myeong Ok Kim, Jungwon Yoon; 2015; Functionalized Magnetic Force Enhances Magnetic Nanoparticle Guidance: From Simulation to Crossing of the Blood-Brain Barrier in vivo; IEEE Transactions on Magnetics