Akhmedullin, Ruslan2024-06-252024-06-252024-04-24Akhmedullin, R. (2024). The Regional Burden of Parkinson’s Disease in Kazakhstan 2014–2021: Insights from National Health Data. Nazarbayev University School of Medicinehttp://nur.nu.edu.kz/handle/123456789/8002Background. Globally, neurological illnesses are the primary cause of disability, with Parkinson's disease (PD) showing the greatest rate of growth. The Global Burden of Disease (GBD) study evaluated 5.5 million Disability-adjusted life-years (DALYs) in 2017. The GBD study underscores the need for research in regions lacking data, such as Central Asia (CA). Methods. Using the Unified National Electronic Health System of Kazakhstan over eight-year span (2014-2021), we explored the epidemiology, DALYs, and all-cause mortality in the PD cohort. Cox proportional hazards regression models and Kaplan-Meier analysis with sensitivity analyses were performed to evaluate the sociodemographic, hypertension and Charlson Comorbidity Index (CCI) affecting survival. Results. The total cohort comprised 10,125 patients, with a significant increase in the prevalence from 4.2 in 2014 to 44.1 in 2021. While mortality rates varied, the eldest (≥80) and youngest (<50) age groups had the highest (137.05) and lowest (16.40) rates per 1000 person-years, respectively. Over the course of observation, 29,474 DALYs were lost due to PD, with a substantial contribution of years of life lost. Finally, there was an increased risk of all-cause mortality among the male sex (adjusted hazard ratio (aHR) 1.6; 1.5-1.8), older age (1.02; 1.01-1.03), greater CCIs and Kazakh ethnicity. Interestingly, patients with comorbid hypertension had higher probability to survive (0.63; 0.57-0.70). Conclusion. To our knowledge, this is the first study in CA to explore the burden of PD. The increasing burden of PD among males and ethnic Kazakhs underscores the necessity for focused interventions. Further efforts must be made to understand the inverse association of hypertension in PD cohort.enParkinson's Disease; Epidemiology; DALYType of access: EmbargoParkinson's DiseaseEpidemiologyDALYMaster's thesis