Sharyktybay, Aiganym2024-10-072024-10-072024Sharyktybay, A. (2024). Periostin Expression in MB49 Cell Line. Nazarbayev University School of Medicinehttps://nur.nu.edu.kz/handle/123456789/8271Periostin is a secreted matricellular protein known to be imbalanced in many pathological conditions, such as tissue repair, fibrosis, inflammation, tumorigenesis, and metastasis. It is often associated with advanced stages of cancer and poor outcomes. Its upregulation in different cancers and ability to develop chemoresistance in cancer tissues suggest its usage as a prognostic biomarker and curing target for prostate, breast, colorectal, pancreatic, gastric, and lung carcinoma. However, there are controversial studies regarding periostin in bladder cancers. The downrate of periostin was an indicator of high-grade bladder cancers, whereas other bladder cancer cell lines showed upregulation of periostin. The current study determined that periostin is expressed in the MB49 mouse bladder cancer cell line and suggested that further research focusing on the effect of periostin upregulation and knockdown on the tumor growth in the MB49 cell line will help cure bladder cancer by targeting periostin in the future.enAttribution-NonCommercial-ShareAlike 3.0 United StatesType of access: RestrictedPeriostinMaster`s thesis