Tokay, T.Mueller, L.Xie, Y.Kirschstein, T.Beck, H.Koehling, R.2016-05-302016-05-302016-05T. Tokay, L. Mueller, Y. Xie, T. Kirschstein, H. Beck, and R. Koehling. 2016. D-series improves learning and memory in epileptic animals. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1518http://nur.nu.edu.kz/handle/123456789/1518The N-methyl-D-aspartate receptor (NMDAR) is critical for the induction of synaptic plasticity and is essential for many forms of learning and memory. Activation of NMDAR by glutamate requires the presence of D-Serine, which is an endogenous physiological coagonist of the receptor and plays an important role in glutamate mediated NMDAR-dependent synaptic plasticity in the brain. However, the role of D-serine in synaptic plasticity and learning in chronic epilepsy is not known.enAttribution-NonCommercial-ShareAlike 3.0 United StatesHippocampusastrocytesepilepsyratD-serineAbstract