Bimurat, Bikadisha2024-11-212024-11-212024Bimurat, B. (2024). Expression patterns of different isoforms of Periostin in cancer development and progression. Nazarbayev University School of Medicinehttps://nur.nu.edu.kz/handle/123456789/8301Extracellular matrix-associated proteins have a key role in modulation of intercellular communication, which is an important mechanism in cancer development and progression. Periostin, a small matricellular protein interacting with different ECM molecules, originally isolated in murine osteoblasts, is involved in both physiologic and pathological processes such as tissue repair, bone growth, epithelial-mesenchymal transition, inflammation, allergies, tumor development and progression. The expression of periostin is markedly elevated in different cancer types (lung, breast, pancreatic, ovarian, colorectal, gastric and other). Even though the contribution of periostin in cellular processes and their underlying mechanisms are still the subject of research, it has widely been reported that periostin drives the process of cell survival, proliferation, and migration. This potential is especially crucial in the context of cancers where periostin contributes to adhesion, invasion, and tumor metastasis. There exist different isoforms of periostin produced by alternative splicing. These different isoforms could have different functions in tumor development and progression. The present study intends to shed light on functions of different periostin isoforms with specific emphasis on periostin isoforms in different cancers.enAttribution-NonCommercial-ShareAlike 3.0 United StatesType of access: GatedMaster`s thesis