Khamkhash, L.Ralchenko, Y.Bukasov, R.2015-10-292015-10-2920149786018046728http://nur.nu.edu.kz/handle/123456789/582Surface-enhanced Raman scattering (SERS) is rapidly evolving as a useful analytical tool in chemical and biological analysis. The most critical aspect of SERS is the research of efficient SERSactive substrates, such as nanostructured surface or nanoparticles of noble metals with suitable physical parameters such as their material, size, shape, and spacing [1]. Generally, Ag and Au substrates are regarded as one of the best candidates for SERS. Nevertheless, fabrication of SERS substrates with both high sensitivity and high reproducibility remains difficult, and it is costly for routine SERS detection. We report the novel combined substrate for highly sensitive Surface Enhanced Raman spectroscopy (SERS) are capable of detecting 4-nitrobenzenethiol (NBT), as a model Raman active molecule, at very low concentration.enbiological analysischemical analysisnanoparticlesmetalsmoleculespectroscopymodel RamanshapeAbstract