Co-expression of FVIII with human IGG FC Fragment or mouse IL-10 in encapsulated G8 myoblast cells as a potential treatment of hemophilia A

Kanketayeva, Zhansaya2018-09-172018-09-172016Zhansaya Kanketayeva. Co-expression of FVIII with human IGG FC Fragment or mouse IL-10 in encapsulated G8 myoblast cells as a potential treatment of hemophilia A. 2016. Nazarbayev University. School of Science and Technologyhttp://nur.nu.edu.kz/handle/123456789/3519In this master thesis study we have shown that recombination G8 myoblasts, encapsulated in alginate-PLL microcapsules can successfully secrete detectable levels of both Fc and IL-10 out of the capsules and sustain good viability, showing the potential of co-delivering FVIII by encapsulated cells.enAttribution-NonCommercial-ShareAlike 3.0 United StatesFVIIIG8IL-10FcCo-expression of FVIII with human IGG FC Fragment or mouse IL-10 in encapsulated G8 myoblast cells as a potential treatment of hemophilia AMaster's thesis