Tvorogova, AnnaSaidova, AleenaSmirnova, TatianaVorobjev, Ivan2020-03-312020-03-312018-12-13Anna Tvorogova, Aleena Saidova, Tatiana Smirnova, Ivan Vorobjev Biology Open 2018 7: bio038968 doi: 10.1242/bio.038968 Published 13 December 2018http://nur.nu.edu.kz/handle/123456789/4577When cells with a mesenchymal type of motility come into contact with an adhesive substrate they adhere and start spreading by the formation of lamellipodia. Using a label-free approach and virtual synchronization approach we analyzed spreading in fibroblasts and cancer cells. In all cell lines spreading is a non-linear process undergoing isotropic or anisotropic modes with first fast (5–20 min) and then slow (30–120 min) phases. In the first 10 min cell area increases 2–4 times, while the absolute rate of initial spreading decreases 2–8 times....enAttribution-NonCommercial-ShareAlike 3.0 United StatesArticle