Poddighe, DimitriRebuffi, ChiaraDe Silvestri, AnnalisaCapittini, Cristina2020-05-062020-05-062020-03-28Poddighe D, Rebuffi C, De Silvestri A, Capittini C. Carrier frequency of HLA-DQB1*02 allele in patients affected with celiac disease: A systematic review assessing the potential rationale of a targeted allelic genotyping as a first-line screening. World J Gastroenterol. 2020;26(12):1365‐1381. doi:10.3748/wjg.v26.i12.136510.3748/wjg.v26.i12.1365http://nur.nu.edu.kz/handle/123456789/4603The final output of this systematic search in the medical literature consisted of 38 studies providing the appropriate HLA-DQB1 genotype information of the respective CD population. According to this systematic review, including a pool of 4945 HLA-DQ genotyped CD patients, the HLA-DQB1*02 carrier frequency was 94.94%, meaning that only 5.06% of CD patients were completely lacking this allelic variant. Interestingly, if we consider only the studies whereby the prevalence of CD patients affected with type 1 diabetes mellitus was supposed or clearly established to be very low, the frequency of non-HLA-DQB1*02 carriers among CD patients dropped to 3.65%.enAttribution-NonCommercial-ShareAlike 3.0 United StatesResearch Subject Categories::MEDICINE::Microbiology, immunology, infectious diseasesArticle