Golriz, MohammadFonouni, HamidrezaKuttymuratov, GaniEsmaeilzadeh, MajidJarahian, ParvinLongerich, ThomasTahmasbi, MorvaFaridar, AlirezaAbbasi, SepehrMehrabi, ArianebGebhard, Marta M.2018-06-062018-06-062015Golriz, Mohammad, Fonouni, Hamidreza, Kuttymuratov, Gani, Esmaeilzadeh, Majid, Jarahian, Parvin, Longerich, Thomas, Tahmasbi, Morva, Faridar, Alireza, Abbasi, Sepehr, Mehrabi, Arianeb, Gebhard, Marta M. (2015) Influence of a modified preservation solution in kidney transplantation: A comparative experimental study in a porcine model. Asian Journal of Surgery10.1016/j.asjsur.2015.07.001http://nur.nu.edu.kz/handle/123456789/3320Currently, due to lack of optimal donors, more marginal organs are transplanted. Therefore, there is a high interest to ameliorate preischemic organ preservation, especially for critical donor organs. In this regard, a new histidinetryptophane ketoglutarate (HTK-N) solution has been designed and its protective efficacy was compared with the standard preservation solutionsdUniversity of Wisconsin solution and standard HTK or Custodiol (Bretschneider’s solution). Methods: Seventy-two landrace pigs were included into the study, as donors and recipients. The donor kidneys were perfused during explantation with cold University of Wisconsin solution (n Z 12), standard HTK (n Z 12), or HTK-N solutions (n Z 12), kept in the respective preservation solution at 4 C for 30 hours, implanted in the recipient pigs, and reperfused. The pigs survived in daily control for 7 days. The serum creatinine and blood urea nitrogen were assessed in pre- and postreperfusion phase on the 3rd day and 7th day posttransplantation. Additionally, tissue samples were taken to analyze the histopathological degree of tubular injury and regeneration before and after reperfusion.enAttribution-NonCommercial-NoDerivs 3.0 United Statesischemia reperfusion injurykidney transplantationpreservation solutionArticle