Olifirenko, ValentinaAbduraimova, AiganymKang, Moon SungRaja, Iruthayapandi SelestinDuisenbayeva, BakytMolkenova, AnaraKhamkhash, LauraHwang, Yoon-HwaeHan, Dong-WookAtabaev, Timur Sh2022-01-202022-01-202021-02-15Olifirenko, V., Abduraimova, A., Kang, M. S., Raja, I. S., Duisenbayeva, B., Molkenova, A., Khamkhash, L., Hwang, Y. H., Han, D. W., & Atabaev, T. S. (2021). Potential applicability of polyethyleneimine PEI-coated Eu2O3 and Dy2O3 nanoparticles for contrast enhancement in computed tomography. Nano Express, 2(1), 010022. https://doi.org/10.1088/2632-959x/abe343http://nur.nu.edu.kz/handle/123456789/5985Rare-earth metal oxide nanoparticles considered promising contrast agents for x-ray computed tomography (CT) and magnetic resonance imaging (MRI). The main purpose of this study is to investigate the potential applicability of polyethyleneimine (PEI)-coated Eu2O3 and Dy2O3 nanoparticles(NPs) for CT x-ray attenuation. Morphology and other physicochemical properties of prepared samples were systematically investigated using a range of characterization tools. Preliminary cytotoxicity experiments with L-929 fibroblastic cells suggested that both samples have no significant toxicity at concentrations below 100 μg ml−1 . Clinical CT analysis shows that PEI@Eu2O3 NPs exhibit higher x-ray attenuation efficiency (∼8 HU mM−1 ) as compared to PEI@Dy2O3 NPs(∼5 HU mM−1 ).enAttribution-NonCommercial-ShareAlike 3.0 United StatesType of access: Open AccessEu2O3, Dy2O3nanoparticlesCT contrast agentscytotoxicitypolyethyleneimineArticle