Mizuno, Y.Kurochkin, I.Schönbach, C.Okzaki, Y.2015-10-302015-10-302013http://nur.nu.edu.kz/handle/123456789/597We applied a sequence- and motif-based, multi-step knowledge discovery strategy to identify novel peroxisome-targeted protein candidates in mouse and human in addition to in vitro and in vivo analyses of mouse regulatory circuits associated with lipid metabolism conditions.The results are likely to be of relevance for some patients with Zellweger Syndrome Spectrum disorders. Detailed structure-function relationships of Tysnd1 with regard to substrate interactions and processing and activation await the determination of its 3D structure.enfirst research weekperoxisomal diseasemedicinescientific researchAbstract