Adarichev, V. A.Sarkar, S.Kalamov, N.Brucker, J.Forde, T. S.Shekhani, M.T.Lyons, B.2015-10-282015-10-282013http://nur.nu.edu.kz/handle/123456789/560We found that Pgis2-congenic mice that carry genetically-deficient copy of C5(Hc) complement component were susceptible to collagen antibody-induced arthritis while inflammation was transient. Using differential gene expression analysis tools, we identified 20 genes whose down/up regulation in Pgis2-congenic mice might rescue C5 complement deficiency or, in a wider sense, rescue the function of the entire Pgis2 locus.enfirst research weekarthritisscienceAbstract