Amirbekov, A.Eraliyeva, L.Zakiryanova, G.2016-05-302016-05-302016-05A. Amirbekov, L. Eraliyeva, G. Zakiryanova. 2016. Alterations of oncogenes expression in human NK cells in cancer patients. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1499http://nur.nu.edu.kz/handle/123456789/1499C-kit/SCF signaling play a key role in regulating NK cell homeostasis, maturation, proliferation and cytotoxicity. C-kit-deficiency in NK results in significant reduction of their, suggesting imperative role fore-kit signaling in NKcell immunobiology. We have recently showed that human NK cells express not only c-kit-receptor, but also both membrane-bound and soluble forms of c-kit ligand - Stem cell factor. The goal of this study was to characterize the c-kit/SCF autocrine loop in peripheral blood NK cells obtained from patients with cancer.enAttribution-NonCommercial-ShareAlike 3.0 United StatesNK cellsc-KitSCFc-MycSTAT3Abstract