Sahin, SezginRomano, MicolGuzel, FerhatPiskin, DavidPoddighe, DimitriSezer, SirenKasapcopur, OzgurAppleton, C. ThomasYilmaz, IlkerDemirkaya, Erkan2023-04-282023-04-282022Sahin, S., Romano, M., Guzel, F., Piskin, D., Poddighe, D., Sezer, S., Kasapcopur, O., Appleton, C. T. G., Yilmaz, I., & Demirkaya, E. (2022). Assessment of Surrogate Markers for Cardiovascular Disease in Familial Mediterranean Fever-Related Amyloidosis Patients Homozygous for M694V Mutation in MEFV Gene. Life, 12(5), 631. https://doi.org/10.3390/life12050631http://nur.nu.edu.kz/handle/123456789/7045Cardiovascular disease (CVD) remains underestimated in familial Mediterranean feverassociated AA amyloidosis (FMF-AA).We aimed to compare early markers of endothelial dysfunction and atherosclerosis in FMF-AA with a homozygous M694V mutation (Group 1 = 76 patients) in the Mediterranean fever (MEFV) gene and in patients with other genotypes (Group 2 = 93 patients). Measures of increased risk for future CVD events and endothelial dysfunction, including flowmediated dilatation (FMD), pentraxin-3 (PTX3), and carotid intima-media thickness (cIMT), and fibroblast growth factor 23 (FGF23) as a marker of atherosclerotic vascular disease were compared between groups. The frequency of clinical FMF manifestations did not differ between the two groups apart from arthritis (76.3% in Group 1 and 59.1% in Group 2, p < 0.05). FMD was significantly lower in Group 1 when compared with Group 2 (MD [95% CI]: 􀀀0.6 [(􀀀0.89)–(􀀀0.31)]). cIMT, FGF23, and PTX3 levels were higher in Group 1 (cIMT MD [95% CI]: 0.12 [0.08–0.16]; FGF23 MD [95% CI]: 12.8 [5.9–19.6]; PTX3 MD [95% CI]: 13.3 [8.9–17.5]). In patients with FMF-AA, M694V homozygosity is associated with lower FMD values and higher cIMT, FGF23, and PTX3 levels, suggesting increased CVD risk profiles. These data suggest that a genotype–phenotype association exists in terms of endothelial dysfunction and atherosclerosis in patients with FMF-AA.enAttribution-NonCommercial-ShareAlike 3.0 United StatesType of access: Open Accessfamilial Mediterranean feverM694V homozygosityAA amyloidosiscardiovascular diseaseflow-mediated dilatationcarotid artery intima-media thicknessArticle