Yeskendirova, Raushan2023-06-052023-06-052023Yeskendirova, R. (2023). Clonogenic capacity of cancer cells after mitotic slippage. School of Sciences and Humanitieshttp://nur.nu.edu.kz/handle/123456789/7182Microtubules are a vital part of eukaryotic cells that assist in many processes, such as cell motility, spreading, intracellular transport, and mitosis. They are polymer structures that comprise α- and β-tubulin heterodimers and form 13 protofilaments. Each α and β monomer has a GTP-binding site. However, GTP bound to the α-tubulin is trapped and never hydrolyzed, whereas GTP on the β-tubulin could be either in GTP- or GDP-bound form and, thus, is exchangeable. The hydrolysis of GTP on the β-tubulin site impacts the microtubular dynamics.enAttribution-NonCommercial-ShareAlike 3.0 United StatesType of access: Open Accesscancer cellsmitotic slippageClonogenic capacityMaster's thesis