Adilzhankyzy, Aina2024-07-042024-07-042024-04Adilzhankyzy, A. (2024). Improving The Specificity And Sensitivity Of Optical Sensors For Biological Purposes. Nazarbayev University School of Engineering and Digital Scienceshttp://nur.nu.edu.kz/handle/123456789/8086The development of antibody-detecting biosensors using interferometric devices is a promising area in biomedical engineering. In this study, a semi-distributed interferometer (SDI) was employed as the biosensor device, utilizing a simplified Fabry-Perot structure. The sensor was functionalized using a combination of surface functionalization and silanization, with nanostructuring to enhance the surface area through the application of gold nanorods. The focus of the research was on the detection of two key biological analytes: the CD44 cancer biomarker and the A33 glycoprotein of the vaccinia poxvirus. The fabrication and functionalization processes were optimized for sensitivity and specificity, with the aim of achieving real-time, label-free detection of these important biomarkersenAttribution-NonCommercial-ShareAlike 3.0 United StatesType of access: RestrictedMaster's thesis