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IS THERE AN ADVANTAGEOUS ARRANGEMENT OF AROMATIC RESIDUES IN PROTEINS? STATISTICAL ANALYSIS OF AROMATIC INTERACTIONS IN GLOBULAR PROTEINS

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dc.contributor.author Lobanov, Mikhail Yu.
dc.contributor.author Pereyaslavets, Leonid B.
dc.contributor.author Likhachev, Ilya V.
dc.contributor.author Matkarimov, Bakhyt T.
dc.contributor.author Galzitskaya, Oxana V.
dc.date.accessioned 2022-02-11T07:32:58Z
dc.date.available 2022-02-11T07:32:58Z
dc.date.issued 2021
dc.identifier.citation Lobanov, M. Y., Pereyaslavets, L. B., Likhachev, I. V., Matkarimov, B. T., & Galzitskaya, O. V. (2021). Is there an advantageous arrangement of aromatic residues in proteins? Statistical analysis of aromatic interactions in globular proteins. Computational and Structural Biotechnology Journal, 19, 5960–5968. https://doi.org/10.1016/j.csbj.2021.10.036 en_US
dc.identifier.uri http://nur.nu.edu.kz/handle/123456789/6041
dc.description.abstract The aim of this study was to evaluate the favorability of different conformations of aromatic residues in proteins by analysing the occurrence of particular conformations. The clustering of protein structures from the Protein Data Bank (PDB) was performed. Conformations of interacting aromatic residues were analyzed for 511 282 pairs in 35 493 protein structures sharing less than 50% identity. Pairs with a par allel arrangement of aromatic residues made up 6.2% of all possible ones, which was twice as much as expected. Pairs with a perpendicular arrangement of aromatic residues made up 25%. We demonstrate that the most favorable arrangement was at an angle of 60 between the interacting aromatic residues. Among all possible aromatic pairs, the His-His pair was twice as frequent as expected, and the His-Phe pair was less frequent than expected. A server (CARP – Contacts of Aromatic Residues in Proteins) has been created for calculating essential structural features of interacting aromatic residues in proteins en_US
dc.language.iso en en_US
dc.publisher Computational and Structural Biotechnology Journal en_US
dc.rights Attribution-NonCommercial-ShareAlike 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/us/ *
dc.subject Type of access: Open Access en_US
dc.subject Aromatic residues en_US
dc.subject Conformation en_US
dc.subject Exhaustive enumeration en_US
dc.subject Stacking en_US
dc.subject Server en_US
dc.subject Protein Data Bank en_US
dc.subject Identity en_US
dc.title IS THERE AN ADVANTAGEOUS ARRANGEMENT OF AROMATIC RESIDUES IN PROTEINS? STATISTICAL ANALYSIS OF AROMATIC INTERACTIONS IN GLOBULAR PROTEINS en_US
dc.type Article en_US
workflow.import.source science


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