Аннотация:
The aim of this study was to evaluate the favorability of different conformations of aromatic residues in
proteins by analysing the occurrence of particular conformations. The clustering of protein structures
from the Protein Data Bank (PDB) was performed. Conformations of interacting aromatic residues were
analyzed for 511 282 pairs in 35 493 protein structures sharing less than 50% identity. Pairs with a par allel arrangement of aromatic residues made up 6.2% of all possible ones, which was twice as much as
expected. Pairs with a perpendicular arrangement of aromatic residues made up 25%. We demonstrate
that the most favorable arrangement was at an angle of 60 between the interacting aromatic residues.
Among all possible aromatic pairs, the His-His pair was twice as frequent as expected, and the His-Phe
pair was less frequent than expected. A server (CARP – Contacts of Aromatic Residues in Proteins) has
been created for calculating essential structural features of interacting aromatic residues in proteins