Role of ROS in AB42 mediated cell surface p-selectin expression and actin polymerization

Abstract

The results of our study have indicated that Aβ42 induces expression of P-selectin on the surface of bEnd3 cells and promotes actin polymerization in a time dependent manner, and all these events correlate with ROS generation. The rapid, posttranslational cell signaling response mediated by ROS, may well represent an important physiological trigger of the micro vascular inflammatory response in AD and requires further investigations.