Creating prerequisites of personalized approach in the diagnosis and treatment of tuberculosis, based on whole genome-sequencing of M.tuberculosis

Abstract

The next generation sequencing technology provides a tool to obtain genetic data from clinically isolates M.tuberculosis. Using it we can clarify the factors cause of the formation of highly virulent strains of M.tuberculosis, the evolution of local strains, and genetic markers of drug resistance, which will pave the personalized approach in the diagnosis and treatment of TB.