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dc.contributor.author Zhabagin, Maxat
dc.contributor.author Sabitov, Zhaxylyk
dc.contributor.author Tarlykov, Pavel
dc.contributor.author Tazhigulova, Inkar
dc.contributor.author Junissova, Zukhra
dc.contributor.author Yerezhepov, Dauren
dc.contributor.author Akilzhanov, Rakhmetolla
dc.contributor.author Zholdybayeva, Elena
dc.contributor.author Wei, Lan-Hai
dc.contributor.author Akilzhanova, Ainur
dc.contributor.author Balanovsky, Oleg
dc.contributor.author Balanovska, Elena
dc.date.accessioned 2021-02-17T11:13:52Z
dc.date.available 2021-02-17T11:13:52Z
dc.date.issued 2020-10-22
dc.identifier.citation Zhabagin, M., Sabitov, Z., Tarlykov, P., Tazhigulova, I., Junissova, Z., Yerezhepov, D., Akilzhanov, R., Zholdybayeva, E., Wei, L.-H., Akilzhanova, A., Balanovsky, O., & Balanovska, E. (2020). The medieval Mongolian roots of Y-chromosomal lineages from South Kazakhstan. BMC Genetics, 21(S1). https://doi.org/10.1186/s12863-020-00897-5 en_US
dc.identifier.issn 1471-2156
dc.identifier.uri https://bmcgenomdata.biomedcentral.com/articles/10.1186/s12863-020-00897-5
dc.identifier.uri https://doi.org/10.1186/s12863-020-00897-5
dc.identifier.uri http://nur.nu.edu.kz/handle/123456789/5316
dc.description.abstract Background: The majority of the Kazakhs from South Kazakhstan belongs to the 12 clans of the Senior Zhuz. According to traditional genealogy, nine of these clans have a common ancestor and constitute the Uissun tribe. There are three main hypotheses of the clans’ origin, namely, origin from early Wusuns, from Niru’un Mongols, or from Darligin Mongols. We genotyped 490 samples of South Kazakhs by 35 Y-chromosomal SNPs (single nucleotide polymorphism) and 17 STRs (short tandem repeat). Additionally, 133 samples from citizen science projects were included into the study. Results: We found that three Uissun clans have unique Y-chromosomal profiles, but the remaining six Uissun clans and one non-Uissun clan share a common paternal gene pool. They share a high frequency (> 40%) of the C2*-ST haplogroup (marked by the SNP F3796), which is associated with the early Niru’un Mongols. Phylogenetic analysis of this haplogroup carried out on 743 individuals from 25 populations of Eurasia has revealed a set of haplotype clusters, three of which contain the Uissun haplotypes. The demographic expansion of these clusters dates back to the 13-fourteenth century, coinciding with the time of the Uissun’s ancestor Maiky-biy known from historical sources. In addition, it coincides with the expansion period of the Mongol Empire in the Late Middle Ages. A comparison of the results with published aDNA (ancient deoxyribonucleic acid) data and modern Y haplogroups frequencies suggest an origin of Uissuns from Niru’un Mongols rather than from Wusuns or Darligin Mongols. Conclusions: The Y-chromosomal variation in South Kazakh clans indicates their common origin in 13th–14th centuries AD, in agreement with the traditional genealogy. Though genetically there were at least three ancestral lineages instead of the traditional single ancestor. The majority of the Y-chromosomal lineages of South Kazakhstan was brought by the migration of the population related to the medieval Niru’un Mongols. Keywords: Human genetics, Y-chromosome, Short tandem repeat, Single nucleotide polymorphism, Time to the most recent common ancestor, Kazakh, Mongol, Wusun en_US
dc.language.iso en en_US
dc.publisher BMC en_US
dc.relation.ispartofseries BMC Genetics;21(S1)
dc.rights Attribution-NonCommercial-ShareAlike 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/us/ *
dc.subject Human genetics en_US
dc.subject Y-chromosome en_US
dc.subject Short tandem repeat en_US
dc.subject Single nucleotide polymorphism en_US
dc.subject Time to the most recent common ancestor en_US
dc.subject Kazakh en_US
dc.subject Mongol en_US
dc.subject Wusun en_US
dc.type Article en_US
workflow.import.source science

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