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MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE
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Browsing Abstracts by Title

Now showing items 21-40 of 95

GENETIC VARIANTS, METABOLOME, AND GUT MICROBIOME BIOMARKERS FOR OBESITY AND AGING IN RANDOMLY SELECTED KAZAKH INDIVIDUALS

Akilzhanova, Ainur; Rakhimova, Saule; Kozhamkulov, Ulan; Kairov, Ulykbek; Kushugulova, Almagul R.; Terwilliger, Joseph; Lee, Joseph (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Objective: Metabolic syndrome (MS) is a cluster of inter-related and heritable metabolic traits, which collectively impart unsurpassed risk for atherosclerotic cardiovascular disease and type 2diabetes. Considerable work ...
GENOTYPING OF MYCOBACTERIUM TUBERCULOSIS ISOLATES AMONG RECURRENT CASES OF TUBERCULOSIS IN KAZAKHSTAN

Akhmetova, A.; Akilzhanova, A.; Toksanbaeva, B.; Bismilda, V.; Chingissova, L.; Kozhamkulov, U. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Introduction: Tuberculosis still remains one of the major health problems in Kazakhstan. According to the World Health Organization data (2018), Kazakhstan is on the list of 30 countries with high rates of multidrug ...
GUT MICROBIOME ALTERATIONS IN SENIORS SUFFERING FROM ALZHEIMER’S DISEASE

Askarova, Sholpan; Kaiyrlykyzy, Aiym; Kozhakhmetov, Samat S.; Nurgaziyev, Madiyar; Kushugulova, Almagul R. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Introduction: One of the important factors influencing human health and attracting increasing attention of scientists during the last two decades is gut microbiome. It has been demonstrated that the links exist between ...
HEREDITARY DISEASES AND CONGENITAL MALFORMATIONS REGISTRATION AND MONITORING INFORMATION SYSTEM

Nazarova, L.; Tolegen, N.; Bayanova, M. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Introduction. Database on hereditary diseases is one of the main tasks of healthcare. Register of hereditary pathology allows to assess accurately the frequency of childbirths with various hereditary diseases and congenital ...
IDENTIFICATION OF KAZAKH SPECIFIC GENOMIC VARIANTS USING COMPARATIVE GENOMICS ANALYSIS

Molkenov, A.; Daniyarov, A.; Sharip, A.; Seisenova, A.; Karabayev, D.; Kairov, U. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Introduction: The modern development of high-performance genomic technologies opens up new possibilities for studying the human genome. Large-scale genomic research generates huge amounts of data, the active development ...
ISOLATION FROM THE KAZAKH TRADITIONAL FOOD PRODUCTS OF A NEW STRAIN OF LACTIC ACID BACTERIA PRODUCING THE HUMAN PLASMINOGEN RECEPTOR

Shaikhin, S.; Abitayeva, G.; Abilhadirov, A.; Dossova, A.; Pirmanova, A.; Tynybaeva, I. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Lactobacillus bacteria are one of the most important groups of the human intestinal microbiota that promote health. Adhesion to host tissues represents a crucial early step in the colonization process of either pathogens ...
ISOLATION OF NATURAL REPRESENTATIVES OF CARP LACTOFLORA TO CREATE PATHOGEN CONTROL AGENTS THAT CAN BE ALTERNATIVE TO ANTIBIOTICS

Urazova, M.; Zakarya, K.; Sarmurzina, Z.; Bissenova, G.; Abitayeva, G.; Shevtsov, A.; Tekebayeva, Zh.; Tynybayeva, I.; Abzhalelov, A. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Currently, the microbiome of commercial fish species is being actively studied. In reviews, mainly based on metagenome analysis features and formation of intestinal microflora of various fish species of North America, ...
LAUNCH OF Q-SYMPHONY BIOINFORMATICS COMPUTING SYSTEM: A HIGH-PERFORMANCE CLUSTER FOR ANALYSIS OF LARGE-SCALE GENOMIC DATASETS

Molkenov, A.; Daniyarov, A.; Sharip, A.; Seisenova, A.; Karabayev, D.; Kairov, U. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Introduction: One whole human genome, provided by next generation sequencing platforms, in raw format takes 20 to 50 GB. In the course of bioinformatics analysis and data analysis, the data volume increases to 300-500 ...
Measures of Reducing the Burden of Health Care Costs by Rational Usage of Laboratory Tests

Marchenko, Y.; Akhmetove, R. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Introduction: Every year manufacturers offer new tests, postulating that it will improve the outcomes of treatment. That results that laboratories have to face an increasing workload combined with a reduction of resources. ...
META-ANALYSIS OF CANCER TRANSCRIPTOMES USING INDEPENDENT COMPONENT ANALYSIS

Seisenova, A.; Sharip, A.; Molkenov, A.; Daniyarov, A.; Karabayev, D.; Kairov, U. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Introduction: Independent Component Analysis (ICA) is a matrix factorization method for data dimension reduction. ICA has been widely applied for the analysis of transcriptomic data for blind separation of biological, ...
Molecular Genetic Approaches in Diagnosis of Duschenne/ Becker Muscular Dystrophy

Bayanova, M.; Uahit, R.; Tolegen, N.; Nazarova, L.; Abilkhadirova, A.; Khamzina, A.; Nauryzbaeva, A.; Jaxybayeva, A. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Introduction: Duchenne/Becker muscular dystrophy (DMD/BMD) is inherited X-linked disease with a frequency of 1: 3,500 newborn males. Deletions and duplications in the DMD gene are errors of reading frameshift and premature ...
MOUSE CYTOKINE-INDUCED KILLER CELLS DEVELOPED FROM DIFFERENT SOURCES

Issabekova, A.; Zhunussova, M.; Zhumabekova, M.; Ogay, V. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Introduction: In Kazakhstan, death from colorectal cancer is on the leading position among cancer-related deaths in the population, and since 2013 colorectal cancer is one of the three cancer diseases subject to the ...
MRI-BASED STUDY OF VARIOUS COGNITIVE IMPAIRMENTS: CROSS-SECTIONAL STUDY

Kossumov, Alibek; Supiyev, Adil (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Introduction: Clinical and diagnostic criteria for cognitive impairments are based neurophysiological tests or the presence of a history of vascular disease and stroke following the MRI scan. Materials and methods: The ...
MULTIDRUG-RESISTANT TUBERCULOSIS: WHOLE-GENOME SEQUENCING AND BIOINFORMATICS ANALYSIS

Kairov, U.; Kozhamkulov, U.; Daniyarov, A.; Molkenov, A.; Akhmetova, A.; Rakhimova, S.; Akilzhanova, A. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Introduction:Tuberculosis (TB) remains a serious public health threat worldwide. It is estimated that approximately one-third of the world’s population has been infected with multidrug-resistant tuberculosis (MDR-TB), ...
MULTIPLE SYSTEM ATROPHY, CEREBELLAR VARIANT: RARE CLINICAL CASE

Akhmetova, Zh.; Isilbaeva, A.; Ainabekova, B.; Kaisarbekova, A.; Meiramova, A.; Imanova, A.; Nabieva, F.; Hydyrpatsha, L. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Introduction: Multisystem atrophy is a rare steadily progressing neurodegenerative disease, manifested by parkinsonism, cerebellar ataxia and autonomic failure. The cerebellar variant of multisystem atrophy is much less ...
MULTIPLEX LIGATION-DEPENDENT PROBE AMPLIFICATION OF MICRODELETION SYNDROMS

Uakhit, R.; Tolegen, N.; Bayanova, M. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Introduction: Microdeletion syndromes are an extensive group of diseases affecting various organs and systems. These diseases are caused by deletions of small sections of chromosomes. Previously, most microdeletion ...
Mutation Analysis of the NRLP3 Gene in Children With Cryopyrin-Associated Fever

Auyeryanova, T.; Uakhit, R.; Assylbekova, M.; Mukusheva, Z.; Bayanova, M. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Introduction: CAPS is a group of severe multi-system, auto-inflammatory diseases with an autosomal dominant type of inheritance associated with mutations in the cryopyrin NLRP3 gene located on the first chromosome (1q44). ...
NEUROPROTECTIVE PROPERTIES OF PLANT EXTRACT FROM LIMONIUM GMELINII

Nurkenov, T.T.; Abzhanova, E.; Turgambayeva, A.; Zhusupova, G.E.; Shalakhmetova, T.M.; Tsoy, A.K.; Askarova, Sh.N. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

logic conditions. When excess ROS are present within the cell, this oxidative stress may have profound deleterious effects on the cell, including the direct oxidation of biomolecules (e.g., lipid, protein, and DNA), ...
Neurosensory Hearing Loss in Children With Bacterial Meningitis

Seidullayeva, A.; Bayasheva, D.; Turdalina, B.; Omarova, A.; Kozhakhmetov, S. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Introduction. Bacterial meningitis (BM) is one of the causes of acquired neurosensory hearing loss in children.In patients undergoing BM, hearing loss is accompanied by ossification of the structural inner ear. Methods: ...
New Screening Options for Patients With Thalassemia: Lebanon Experience

Andrusha, A.B.; Mohamad, B.S. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Introduction: Morbidity and mortality in beta thalassemia are caused by anemia and iron overload. The prognosis of patients with thalassemia major depends on the patient’s adherence to treatment programs. The early ...