Browsing Chemistry by Author "Somlyo, Avril V."

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Bacterial expression, purification and in Vitro phosphorylation of full-length ribosomal S6 kinase 2 (RSK2)

Utepbergenov, Darkhan; Hennig, Paulina M.; Derewenda, Urszula; Artamonov, Mykhaylo V.; Somlyo, Avril V.; Derewenda, Zygmunt S. (PLoS One, 2016-10-01)

Ribosomal S6 kinases (RSK) play important roles in cell signaling through the mitogen-activated protein kinase (MAPK) pathway. Each of the four RSK isoforms (RSK1-4) is a single polypeptide chain containing two kinase ...
The p90 Ribosomal S6 Kinase (RSK) Is a Mediator of Smooth Muscle Contractility

Artamonov, Mykhaylo; Momotani, Ko; Utepbergenov, Darkhan; Franke, Aaron; Khromov, Alexander; Derewenda, Zygmunt S.; Somlyo, Avril V. (2013)

In the canonical model of smooth muscle (SM) contraction, the contractile force is generated by phosphorylation of the myosin regulatory light chain (RLC20) by the myosin light chain kinase (MLCK). Moreover, phosphorylation ...