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Hyperbaric oxygenation and glucose/amino acids substitution in human severe placental insufficiency

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dc.contributor.author Tchirikov, Michael
dc.contributor.author Saling, Erich
dc.contributor.author Bapayeva, Gauri
dc.contributor.author Bucher, Michael
dc.contributor.author Thews, Oliver
dc.contributor.author Seliger, Gregor
dc.date.accessioned 2020-05-20T06:00:56Z
dc.date.available 2020-05-20T06:00:56Z
dc.date.issued 2018-03-13
dc.identifier.citation Tchirikov, M., Saling, E., Bapayeva, G., Bucher, M., Thews, O., & Seliger, G. (2018). Hyperbaric oxygenation and glucose/amino acids substitution in human severe placental insufficiency. Physiological Reports, 6(5), e13589. https://doi.org/10.14814/phy2.13589 en_US
dc.identifier.issn 2051-817X
dc.identifier.other 10.14814/phy2.13589
dc.identifier.uri https://doi.org/10.14814/phy2.13589
dc.identifier.uri https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.13589
dc.identifier.uri http://nur.nu.edu.kz/handle/123456789/4747
dc.description.abstract In the first case, the AA and glucose were infused through a perinatal port system into the umbilical vein at 30 weeks' gestation due to severe IUGR. The patient received daily hyperbaric oxygenation (HBO, 100% O2) with 1.4 atmospheres absolute for 50 min for 7 days. At 31+4 weeks' gestation, the patient gave birth spontaneously to a newborn weighing 1378 g, pH 7.33, APGAR score 4/6/intubation. In follow‐up examinations at 5 years of age, the boy was doing well without any neurological disturbance or developmental delay. In the second case, the patient presented at 25/5 weeks' gestation suffering from severe IUGR received HBO and maternal AA infusions. The cardiotocography was monitored continuously during HBO treatment. The short‐time variations improved during HBO from 2.9 to 9 msec. The patient developed pathologic CTG and uterine contractions 1 day later and gave birth to a hypotrophic newborn weighing 420 g. After initial adequate stabilization, the extremely preterm newborn unfortunately died 6 days later. Fetal nutrition combined with HBO is technically possible and may allow the prolongation of the pregnancy. Fetal‐specific amino‐acid composition would facilitate the treatment options of IUGR fetuses and extremely preterm newborn. en_US
dc.language.iso en en_US
dc.publisher Wiley Open Access en_US
dc.relation.ispartofseries Physiological Reports;
dc.rights Attribution-NonCommercial-ShareAlike 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/us/ *
dc.subject Amino acids en_US
dc.subject cordocentesis en_US
dc.subject fetal growthrestriction en_US
dc.subject HBO en_US
dc.subject hyperbaric oxygenation en_US
dc.subject intrauterine treatment en_US
dc.subject intravenous infusion en_US
dc.subject IUGR en_US
dc.subject placental insufficiency en_US
dc.subject portimplantation en_US
dc.title Hyperbaric oxygenation and glucose/amino acids substitution in human severe placental insufficiency en_US
dc.type Article en_US
workflow.import.source science


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