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Fe3O4 Nanoparticles for Complex Targeted Delivery and Boron Neutron Capture Therapy

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dc.contributor.author Dukenbayev, Kanat
dc.contributor.author Korolkov, I. V.
dc.contributor.author Tishkevich, Dania
dc.contributor.author Kozlovskiy, Artem
dc.contributor.author Trukhanov, Sergey
dc.contributor.author Gorin, Yevgeniy
dc.contributor.author Shumskaya, Elena
dc.contributor.author Kaniukov, E. Yu.
dc.contributor.author Vinnik, Denis
dc.contributor.author Zdorovets, M. V.
dc.contributor.author Anisovich, Marina
dc.contributor.author Trukhanov, Alex
dc.contributor.author Tosi, Daniele
dc.contributor.author Molardi, Carlo
dc.date.accessioned 2019-12-12T03:19:43Z
dc.date.available 2019-12-12T03:19:43Z
dc.date.issued 2019-04
dc.identifier.citation Dukenbayev, K., Korolkov, I., Tishkevich, D., Kozlovskiy, A., Trukhanov, S., Gorin, Y., … Molardi, C. (2019). Fe3O4 Nanoparticles for Complex Targeted Delivery and Boron Neutron Capture Therapy. Nanomaterials, 9(4), 494. https://doi.org/10.3390/nano9040494 en_US
dc.identifier.other 10.3390/nano9040494
dc.identifier.uri http://nur.nu.edu.kz/handle/123456789/4401
dc.description https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523109/ en_US
dc.description.abstract Magnetic Fe3O4 nanoparticles (NPs) and their surface modification with therapeutic substances are of great interest, especially drug delivery for cancer therapy, including boron-neutron capture therapy (BNCT). In this paper, we present the results of boron-rich compound (carborane borate) attachment to previously aminated by (3-aminopropyl)-trimethoxysilane (APTMS) iron oxide NPs. Fourier transform infrared spectroscopy with Attenuated total reflectance accessory (ATR-FTIR) and energy-dispersive X-ray analysis confirmed the change of the element content of NPs after modification and formation of new bonds between Fe3O4 NPs and the attached molecules. Transmission (TEM) and scanning electron microscopy (SEM) showed Fe3O4 NPs’ average size of 18.9 nm. Phase parameters were studied by powder X-ray diffraction (XRD), and the magnetic behavior of Fe3O4 NPs was elucidated by Mössbauer spectroscopy. The colloidal and chemical stability of NPs was studied using simulated body fluid (phosphate buffer—PBS). Modified NPs have shown excellent stability in PBS (pH = 7.4), characterized by XRD, Mössbauer spectroscopy, and dynamic light scattering (DLS). Biocompatibility was evaluated in-vitro using cultured mouse embryonic fibroblasts (MEFs). The results show us an increasing of IC50 from 0.110 mg/mL for Fe3O4 NPs to 0.405 mg/mL for Fe3O4-Carborane NPs. The obtained data confirm the biocompatibility and stability of synthesized NPs and the potential to use them in BNCT. en_US
dc.language.iso en en_US
dc.publisher MDPI en_US
dc.rights Attribution-NonCommercial-ShareAlike 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/us/ *
dc.subject magnetic nanoparticles en_US
dc.subject iron oxide en_US
dc.subject surface functionalization en_US
dc.subject APTMS en_US
dc.subject carborane en_US
dc.title Fe3O4 Nanoparticles for Complex Targeted Delivery and Boron Neutron Capture Therapy en_US
dc.type Article en_US
workflow.import.source science

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