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Relevance of HLA-DQB1*02 Allele in the Genetic Predisposition of Children with Celiac Disease: Additional Cues from a Meta-Analysis

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dc.contributor.author Capittini, Cristina
dc.contributor.author De Silvestri, Annalisa
dc.contributor.author Rebuffi, Chiara
dc.contributor.author Tinelli, Carmine
dc.contributor.author Poddighe, Dimitri
dc.date.accessioned 2019-12-12T03:19:38Z
dc.date.available 2019-12-12T03:19:38Z
dc.date.issued 2019-05
dc.identifier.citation Capittini, C., De Silvestri, A., Rebuffi, C., Tinelli, C., & Poddighe, D. (2019). Relevance of HLA-DQB1*02 Allele in the Genetic Predisposition of Children with Celiac Disease: Additional Cues from a Meta-Analysis. Medicina, 55(5), 190. https://doi.org/10.3390/medicina55050190 en_US
dc.identifier.other 10.3390/medicina55050190
dc.identifier.uri http://nur.nu.edu.kz/handle/123456789/4398
dc.description https://www.ncbi.nlm.nih.gov/pubmed/31121940 en_US
dc.description.abstract Background and Objectives: Celiac disease (CD) is a multifactorial immune-mediated disorder, triggered by the ingestion of gluten in genetically-predisposed subjects carrying MHC-DQ2 and -DQ8 heterodimers, which are encoded by four HLA-DQ allelic variants, overall. This meta-analysis aims at providing further epidemiological support to the predominant relevance of one specific allele, namely HLA-DQB1*02, in the predisposition and genetic risk of CD. Materials and Methods: We performed a search of MEDLINE/PubMed, Embase, Web of Science, and Scopus, retrieving all publications (case-control study, cross-sectional, and retrospective cohort study) on the association between HLA class II polymorphisms and first-degree relatives (FDRs) of children with CD. After a critical reading of the articles, two investigators independently performed data extraction according to the following inclusion criteria: HLA class II genes, any DQ and DR molecules, and CD diagnosed following the current clinical guidelines. A third participant was consulted for discussion to reach an agreement concerning discrepancies. Results: Our search strategy selected 14 studies as being eligible for inclusion, and those were submitted for data extraction and analysis. These studies were published between 1999 and 2016 and, collectively, enrolled 3063 FDRs. Positive and negative likelihood ratios (LR+ and LR-, respectively) for CD diagnosis, according to the presence of the HLA-DQ genotype coding a complete MHC-DQ2 and/or MHC-DQ8 molecules, were 1.449 (CI 1.279-1.642) and 0.187 (CI 0.096-0.362), respectively. If only the isolated presence of HLA-DQB1*02 allele is considered, the pooled estimation of LR+ was 1.659 (CI 1.302-2.155) and, importantly, the LR- still showed a very good discriminatory power of 0.195 (CI 0.068-0.558). Conclusions: Through our differential meta-analysis, comparing the presence of the genotype coding the full MHC-DQ2 and/or DQ8 molecules with the isolated presence of HLA-DQB1*02 allelic variant, we found that the LR- of the latter analysis maintained the same value. This observation, along with previous evidences, might be useful to consider potential cost-effective widened screening strategies for CD in children. en_US
dc.language.iso en en_US
dc.publisher MDPI en_US
dc.rights Attribution-NonCommercial-ShareAlike 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/us/ *
dc.subject celiac disease en_US
dc.subject children en_US
dc.subject HLA-DQB1*02 en_US
dc.subject screening en_US
dc.subject first-degree relatives en_US
dc.title Relevance of HLA-DQB1*02 Allele in the Genetic Predisposition of Children with Celiac Disease: Additional Cues from a Meta-Analysis en_US
dc.type Article en_US
workflow.import.source science

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