Browsing Laboratory of Bioinformatics and Systems Biology by Author "cd963eb1-4a50-4481-8f35-d10e3b381b8a"

Now showing items 1-1 of 1

Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution

Kairov, Ulykbek; Aynaud, Marie-Ming; Mirabeau, Olivier; Gruel, Nadege; Grossetête, Sandrine; Boeva, Valentina; Durand, Simon; Surdez, Didier; Zaïdi, Sakina; Gribkova, Svetlana; Fouché, Aziz; Raynal, Virginie; Tirode, Franck; Grünewald, Thomas G P; Bohec, Mylene; Baulande, Sylvain; Janoueix-Lerosey, Isabelle; Vert, Jean-Philippe; Barillot, Emmanuel (Cell Press, 2020-02-11)

EWSR1-FLI1, the chimeric oncogene specific for Ewing sarcoma (EwS), induces a cascade of signaling events leading to cell transformation. However, it remains elusive how genetically homogeneous EwS cells can drive the ...