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  • Imaging flow cytometry for phytoplankton analysis 
    Dashkova, Veronika; Malashenkov, Dmitry; Poulton, Nicole; Vorobjev, Ivan; Barteneva, Natasha S. (MethodsMethods, 2017-01-01)
    Abstract This review highlights the concepts and instrumentation of imaging flow cytometry technology and in particular its use for phytoplankton analysis. Imaging flow cytometry, a hybrid technology combining speed and ...
  • Immune phenotypes predict survival in patients with glioblastoma multiforme 
    Mostafa, Haouraa; Pala, Andrej; Högel, Josef; Hlavac, Michal; Dietrich, Elvira; Westhoff, M. Andrew; Nonnenmacher, Lisa; Burster, Timo; Georgieff, Michael; Wirtz, C. Rainer; Schneider, E. Marion (Journal of Hematology and Oncology, 2016-09-01)
    Background: Glioblastoma multiforme (GBM), a common primary malignant brain tumor, rarely disseminates beyond the central nervous system and has a very bad prognosis. The current study aimed at the analysis of ...
  • InCoB2013 introduces Systems Biology as a major conference theme 
    Schönbach, Christian; Shen, Bairong; Tan, Tin Wee; Ranganathan, Shoba (BMC, 2013-09)
    The Asia-Pacific Bioinformatics Network (APBioNet) held the first International Conference on Bioinformatics (InCoB) in Bangkok in 2002 to promote North-South networking. Commencing as a forum for Asia-Pacific researchers ...
  • InCoB2014: Bioinformatics to tackle the data to knowledge challenge 
    Ranganathan, Shoba; Tan, Tin Wee; Schönbach, Christian (BMC Bioinformatics, 2014-12-08)
    Since 2006, the International Conference on Bioinformatics (InCoB) has been publishing selected papers in BMC Bioinformatics. Papers within the scope of the journal from the 13th InCoB July 31-2 August, 2014 in Sydney, ...
  • InCoB2014: Mining Biological Data From Genomics for Transforming Industry and Health 
    Schönbach, Christian; Tan, Tin Wee; Ranganathan, Shoba (BMC, 2014)
    The 13th International Conference on Bioinformatics (InCoB2014) was held for the first time in Australia, at Sydney, July 31-2 August, 2014. InCoB is the annual scientific gathering of the Asia-Pacific Bioinformatics Network ...
  • Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1 
    Jin, Yong-Ri; Stohn, J. Patrizia; Wang, Qiaozeng; Nagano, Kenichi; Baron, Roland; Bouxsein, Mary L.; Rosen, Clifford J.; Adarichev, Vyacheslav A.; Lindner, Volkhard (Bone, 2017-04-01)
    Abstract Collagen triple helix repeat-containing1 (Cthrc1) has previously been implicated in osteogenic differentiation and positive regulation of bone mass, however, the underlying mechanisms remain unclear. Here we ...
  • INVOLVEMENT OF 3′,5′-CYCLIC INOSINE MONOPHOSPHATE IN CYSTATHIONINE Γ-LYASE-DEPENDENT REGULATION OF THE VASCULAR TONE 
    Mitidieri, Emma; Vellecco, Valentina; Brancaleone, Vincenzo; Vanacore, Domenico; Manzo, Onorina L.; Martin, Emil; Sharina, Iraida; Krutsenko, Yekaterina; Monti, Maria Chiara; Morretta, Elva; Papapetropoulos, Andreas; Caliendo, Giuseppe; Frecentese, Francesco; Cirino, Giuseppe; Sorrentino, Raffaella; Bianca, Roberta d'Emmanuele di Villa; Bucci, Mariarosaria (British Journal of Pharmacology, 2021-04-30)
    l-cysteine or hydrogen sulfide (H2S) donors induce a biphasic effect on precontracted isolated vessels. The contractile effect occurs within a concentration range of 10 nM to 3 μM followed by vasodilatation at 30–100 μM. ...
  • Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G 
    Eipper, Steffen; Steiner, Robin; Lesner, Adam; Sienczyk, Marcin; Palesch, David; Halatsch, Marc- Eric; Zaczynska, Ewa; Heim, Christopher; Hartmann, Marcus D.; Zimecki, Michal; Rainer Wirtz, Christian; Burster, Timo (PLOS ONE, 2016-03-17)
    Protease-mediated degradation of proteins is critical in a plethora of physiological processes. Neutrophils secrete serine proteases including cathepsin G (CatG), neutrophile elastase (NE), and proteinase 3 (PR3) together ...
  • Multi-parametric imaging of cell heterogeneity in apoptosis analysis 
    Vorobjev, Ivan A.; Barteneva, Natasha S. (Methods, 2017-01-01)
    Abstract Apoptosis is a multistep process of programmed cell death where different morphological and molecular events occur simultaneously and/or consequently. Recent progress in programmed cell death analysis uncovered ...
  • Nickel(II) and nickel(0) complexes of bis(diisopropylphosphino)amine: Synthesis, structure, and electrochemical activity 
    Dickie, Diane A.; Chacon, Brittany E.; Issabekov, Alibek; Lam, Kevin; Kemp, Richard A. (Inorganica Chimica Acta, 2016-11-01)
    Abstract In its neutral state, bis(diisopropylphosphino)amine HL reacts in equimolar amounts with the nickel halides NiCl2·6H2O, NiBr2, and NiI2 in ethanol solutions to give the air- and moisture-stable P,P-chelated complexes ...
  • Pathogen-driven gastrointestinal cancers: Time for a change in treatment paradigm? 
    Aituov, Bauyrzhan; Duisembekova, Assem; Bulenova, Assel; Alibek, Kenneth (Infectious Agents and Cancer, 2012)
    The regulation of cancerous tumor development is converged upon by multiple pathways and factors. Besides environmental factors, gastrointestinal (GI) tract cancer can be caused by chronic inflammation, which is generally ...
  • Polymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstan 
    Iskakova, Aisha N.; Romanova, Aliya A.; Aitkulova, Akbota M.; Sikhayeva, Nurgul S.; Zholdybayeva, Elena V.; Ramanculov, Erlan M. (BMC Genetics, 2016-01-19)
    Background: Studies of genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs are crucial to the development of therapeutics in clinical medicine. Such data provide information that may ...
  • Proposal for assessment of the antimicrobial efficacy of undiluted medical honey: Using a standardized phase 2/step 2 in vitro stainless steel disc carrier test model 
    Goerdt, Anna-Maria; Assadian, Ojan; Razavi, Behzad; Igelbrink-Holter, Dorothee; Simon, Arne; Hübner, Nils-Olaf; Partecke, Lars Ivo; Zhumadilova, Anara; Heidecke, Claus-Dieter; Kramer, Axel (Wound Medicine, 2013-07-01)
    Abstract PurposeThe antimicrobial efficacy of medical honeys used for professional wound care was published previously. So far, all in vitro antimicrobial tests performed have been conducted using non-standardized methods ...
  • A quarter of patients with type 1 diabetes have co-existing non-islet autoimmunity: the findings of a UK population-based family study. 
    Kozhakhmetova, A; Wyatt, RC; Caygill, C; Williams, C; Long, AE; Chandler, K; Aitken, RJ; Wenzlau, JM; Davidson, HW; Gillespie, KM; Williams, AJK (Clinical and Experimental Immunology, 2018-03-24)
    Individuals with type 1 diabetes (T1D) are at increased risk of coeliac disease (CD), autoimmune thyroiditis and autoimmune gastritis, but the absolute risks are unclear. The aim of this study was to investigate the ...
  • Regulation of Cathepsin G Reduces the Activation of Proinsulin-Reactive T Cells from Type 1 Diabetes Patients 
    Zou, Fang; Schafer, Nadja; Palesch, David; Brucken, Ruth; Beck, Alexander; Sienczyk, Marcin; Kalbacher, Hubert; Sun, ZiLin; Boehm, Bernhard O.; Burster, Timo (PLoS ONE, 2011-08-05)
    Autoantigenic peptides resulting from self-proteins such as proinsulin are important players in the development of type 1 diabetes mellitus (T1D). Self-proteins can be processed by cathepsins (Cats) within endocytic ...
  • Re: Long-term Psychological and Quality-of-life Effects of Active Surveillance and Watchful Waiting After Diagnosis of Low-risk Localised Prostate Cancer 
    Ibragimova, Nazgul; Zhanzak, Zhuldyz; Meyerbekova, Aizhan; Xie, Yingqiu (European Urology, 2018-01-01)
    Egger et al performed a 10-yr cohort study among 52–79-yr-old men diagnosed with low-risk localized prostate cancer. The objective of this research was to test permanent psychological and quality-of-life effects after ...
  • Reverse the Resistance to PARP Inhibitors 
    Kim, Yevgeniy; Kim, Aleksei; Sharip, Ainur; Sharip, Aigul; Jiang, Juhong; Yang, Qing; Xie, Yingqiu (International Journal of Biological Sciences, 2017-02-17)
    One of the DNA repair machineries is activated by Poly (ADP-ribose) Polymerase (PARP) enzyme. Particularly, this enzyme is involved in repair of damages to single-strand DNA, thus decreasing the chances of generating ...
  • A Scorpion Defensin BmKDfsin4 Inhibits Hepatitis B Virus Replication in Vitro 
    Zeng, Zhengyang; Zhang, Qian; Hong, Wei; Xie, Yingqiu; Liu, Yun; Li, Wenxin; Wu, Yingliang; Cao, Zhijian (MDPI, 2016-04-27)
    Hepatitis B virus (HBV) infection is a major worldwide health problem which can cause acute and chronic hepatitis and can significantly increase the risk of liver cirrhosis and primary hepatocellular carcinoma (HCC). ...
  • Targeting Mechanotransduction at theTranscriptional Level: YAPandBRD4 Are Novel Therapeutic Targets for the Reversal of Liver Fibrosis 
    Zhubanchaliyev, Altynbek; Temirbekuly, Aibar; Kongrtay, Kuralay; Wanshura, Leah C.; Kunz, Jeannette (Frontiers in Pharmacology, 2016-12-01)
    Liver fibrosis is the result of a deregulated wound healing process characterized by the excessive deposition of extracellular matrix. Hepatic stellate cells (HSCs), which are activated in response to liver injury, are the ...
  • Type 1 Diabetes: Current Perspectives 
    Kozhakhmetova, A; Gillespie, KM (Methods in Molecular Biology, 2016)
    Type 1 diabetes, resulting from the autoimmune destruction of insulin producing islet beta cells is caused by genetic and environmental determinants. Recent studies agree that counterintuitively, the major genetic ...

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