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  • A Scorpion Defensin BmKDfsin4 Inhibits Hepatitis B Virus Replication in Vitro 
    Zeng, Zhengyang; Zhang, Qian; Hong, Wei; Xie, Yingqiu; Liu, Yun; Li, Wenxin; Wu, Yingliang; Cao, Zhijian (MDPI, 2016-04-27)
    Hepatitis B virus (HBV) infection is a major worldwide health problem which can cause acute and chronic hepatitis and can significantly increase the risk of liver cirrhosis and primary hepatocellular carcinoma (HCC). ...
  • Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation 
    Sun, Xiaoming; Shi, Yi; Akahoshi, Tomohiro; Fujiwara, Mamoru; Gatanaga, Hiroyuki; Schönbach, Christian; Kuse, Nozomi; Appay, Victor; Gao, George F.; Oka, Shinichi; Takiguchi, Masafumi (Cell Reports, 2016-06-07)
    Summary The mechanistic basis for the progressive accumulation of Y135F Nef mutant viruses in the HIV-1-infected population remains poorly understood. Y135F viruses carry the 2F mutation within RW8 and RF10, which are two ...
  • Immune phenotypes predict survival in patients with glioblastoma multiforme 
    Mostafa, Haouraa; Pala, Andrej; Högel, Josef; Hlavac, Michal; Dietrich, Elvira; Westhoff, M. Andrew; Nonnenmacher, Lisa; Burster, Timo; Georgieff, Michael; Wirtz, C. Rainer; Schneider, E. Marion (Journal of Hematology and Oncology, 2016-09-01)
    Background: Glioblastoma multiforme (GBM), a common primary malignant brain tumor, rarely disseminates beyond the central nervous system and has a very bad prognosis. The current study aimed at the analysis of ...
  • Exogenous cathepsin G upregulates cell surface MHC class I molecules on immune and glioblastoma cells 
    Giese, Madleen; Turiello, Nadine; Molenda, Nicole; Palesch, David; Meid, Annika; Schroeder, Roman; Basilico, Paola; Benarafa, Charaf; Halatsch, Marc-Eric; Zimecki, Michal; Westhoff, Mike-Andrew; Rainer Wirtz, Christian; Burster, Timo (Oncotarget, 2016-10-28)
    Major histocompatibility complex (MHC) class I molecules present antigenic peptides to cytotoxic T cells. During an adaptive immune response, MHC molecules are regulated by several mechanisms including lipopolysaccharide ...
  • Nickel(II) and nickel(0) complexes of bis(diisopropylphosphino)amine: Synthesis, structure, and electrochemical activity 
    Dickie, Diane A.; Chacon, Brittany E.; Issabekov, Alibek; Lam, Kevin; Kemp, Richard A. (Inorganica Chimica Acta, 2016-11-01)
    Abstract In its neutral state, bis(diisopropylphosphino)amine HL reacts in equimolar amounts with the nickel halides NiCl2·6H2O, NiBr2, and NiI2 in ethanol solutions to give the air- and moisture-stable P,P-chelated complexes ...
  • Targeting Mechanotransduction at theTranscriptional Level: YAPandBRD4 Are Novel Therapeutic Targets for the Reversal of Liver Fibrosis 
    Zhubanchaliyev, Altynbek; Temirbekuly, Aibar; Kongrtay, Kuralay; Wanshura, Leah C.; Kunz, Jeannette (Frontiers in Pharmacology, 2016-12-01)
    Liver fibrosis is the result of a deregulated wound healing process characterized by the excessive deposition of extracellular matrix. Hepatic stellate cells (HSCs), which are activated in response to liver injury, are the ...
  • Epidemiology of Brucellosis and Genetic Diversity of Brucella abortus in Kazakhstan 
    Shevtsova, Elena; Shevtsov, Alexandr; Mukanov, Kasim; Filipenko, Maxim; Kamalova, Dinara; Sytnik, Igor; Syzdykov, Marat; Kuznetsov, Andrey; Akhmetova, Assel; Zharova, Mira; Karibaev, Talgat; Tarlykov, Pavel; Ramanculov, Erlan (Plos One, 2016-12-01)
    Brucellosis is a major zoonotic infection in Kazakhstan. However, there is limited data on its incidence in humans and animals, and the genetic diversity of prevalent strains is virtually unstudied. Additionally, there is ...
  • Multi-parametric imaging of cell heterogeneity in apoptosis analysis 
    Vorobjev, Ivan A.; Barteneva, Natasha S. (Methods, 2017-01-01)
    Abstract Apoptosis is a multistep process of programmed cell death where different morphological and molecular events occur simultaneously and/or consequently. Recent progress in programmed cell death analysis uncovered ...
  • Imaging flow cytometry analysis of intracellular pathogens 
    Haridas, Viraga; Ranjbar, Shahin; Vorobjev, Ivan A.; Goldfeld, Anne E.; Barteneva, Natasha S. (Methods, 2017-01-01)
    Abstract Imaging flow cytometry has been applied to address questions in infection biology, in particular, infections induced by intracellular pathogens. This methodology, which utilizes specialized analytic software makes ...
  • Imaging flow cytometry for phytoplankton analysis 
    Dashkova, Veronika; Malashenkov, Dmitry; Poulton, Nicole; Vorobjev, Ivan; Barteneva, Natasha S. (MethodsMethods, 2017-01-01)
    Abstract This review highlights the concepts and instrumentation of imaging flow cytometry technology and in particular its use for phytoplankton analysis. Imaging flow cytometry, a hybrid technology combining speed and ...
  • Reverse the Resistance to PARP Inhibitors 
    Kim, Yevgeniy; Kim, Aleksei; Sharip, Ainur; Sharip, Aigul; Jiang, Juhong; Yang, Qing; Xie, Yingqiu (International Journal of Biological Sciences, 2017-02-17)
    One of the DNA repair machineries is activated by Poly (ADP-ribose) Polymerase (PARP) enzyme. Particularly, this enzyme is involved in repair of damages to single-strand DNA, thus decreasing the chances of generating ...
  • Autoantibodies to tissue transglutaminase target epitopes dependent on residues in the N-terminal domain 
    Kozhakhmetova, A; Wyatt, R; Elvers, K; Emery, D; Williams, C; Annis, P; Lampasona, V; Gillespie, K; Williams, A (Coeliac UK's Research Conference, 2017-03-24)
    INTRODUCTION: Tissue transglutaminase (tTG), is the main autoantigen of coeliac disease (CD). Specific tTG epitopes, including N-and C-terminal sites as well as the catalytic triad, have been reported to be targeted by ...
  • Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1 
    Jin, Yong-Ri; Stohn, J. Patrizia; Wang, Qiaozeng; Nagano, Kenichi; Baron, Roland; Bouxsein, Mary L.; Rosen, Clifford J.; Adarichev, Vyacheslav A.; Lindner, Volkhard (Bone, 2017-04-01)
    Abstract Collagen triple helix repeat-containing1 (Cthrc1) has previously been implicated in osteogenic differentiation and positive regulation of bone mass, however, the underlying mechanisms remain unclear. Here we ...
  • Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study 
    Sikhayeva, Nurgul; Iskakova, Aisha; Saigi-Morgui, Nuria; Zholdybaeva, Elena; Eap, Chin-Bin; Ramanculov, Erlan (BMC Medical Genetics, 2017-07-24)
    Background: We evaluated the associations between single nucleotide polymorphisms and different clinical parameters related to type 2 diabetes mellitus (T2DM), obesity risk, and metabolic syndrome (MS) in a Kazakh cohort. ...
  • CFD Modeling of Chamber Filling in a Micro- Biosensor for Protein Detection 
    Islamov, Meiirbek; Sypabekova, Marzhan; Kanayeva, Damira; Rojas-Solórzano, Luis (Biosensors, 2017-10)
    Tuberculosis (TB) remains one of the main causes of human death around the globe. The mortality rate for patients infected with active TB goes beyond 50% when not diagnosed. Rapid and accurate diagnostics coupled with ...
  • Extracellular vesicles in gastrointestinal cancer in conjunction with microbiota: On the border of Kingdoms 
    Barteneva, Natasha S.; Baiken, Yeldar; Fasler-Kan, Elizaveta; Alibek, Kenneth; Wang, Sheng; Maltsev, Natalia; Ponomarev, Eugene D.; Sautbayeva, Zarina; Kauanova, Sholpan; Moore, Anna; Beglinger, Christoph; Vorobjev, Ivan A. (Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2017-12-01)
    Abstract Extracellular vesicle (EV) production is a universal feature of metazoan cells as well as prokaryotes (bMVs - bacterial microvesicles). They are small vesicles with phospholipid membrane carrying proteins, DNA and ...
  • Re: Long-term Psychological and Quality-of-life Effects of Active Surveillance and Watchful Waiting After Diagnosis of Low-risk Localised Prostate Cancer 
    Ibragimova, Nazgul; Zhanzak, Zhuldyz; Meyerbekova, Aizhan; Xie, Yingqiu (European Urology, 2018-01-01)
    Egger et al performed a 10-yr cohort study among 52–79-yr-old men diagnosed with low-risk localized prostate cancer. The objective of this research was to test permanent psychological and quality-of-life effects after ...
  • A quarter of patients with type 1 diabetes have co-existing non-islet autoimmunity: the findings of a UK population-based family study. 
    Kozhakhmetova, A; Wyatt, RC; Caygill, C; Williams, C; Long, AE; Chandler, K; Aitken, RJ; Wenzlau, JM; Davidson, HW; Gillespie, KM; Williams, AJK (Clinical and Experimental Immunology, 2018-03-24)
    Individuals with type 1 diabetes (T1D) are at increased risk of coeliac disease (CD), autoimmune thyroiditis and autoimmune gastritis, but the absolute risks are unclear. The aim of this study was to investigate the ...
  • Characterization of biochemical properties of an apurinic/apyrimidinic endonuclease from Helicobacter pylori 
    Turgimbayeva, Aigerim; Abeldenov, Sailau; Zharkov, Dmitry O.; Ishchenko, Alexander A.; Ramankulov, Yerlan; Saparbaev, Murat; Khassenov, Bekbolat (PLoS ONE, 2018-08-15)
    Apurinic/apyrimidinic (AP) endonucleases play critical roles in the repair of abasic sites and strand breaks in DNA. Complete genome sequences of Helicobacter pylori reveal that this bacterial specie has a single AP ...
  • Genetic Diversity of Brucella melitensis in Kazakhstan in Relation to World-Wide Diversity 
    Shevtsova, Elena; Vergnaud, Gilles; Shevtsov, Alexandr; Shustov, Alexandr; Berdimuratova, Kalysh; Mukanov, Kasim; Syzdykov, Marat; Kuznetsov, Andrey; Lukhnova, Larissa; Izbanova, Uinkul; Filipenko, Maxim; Ramankulov, Yerlan (FRONTIERS MEDIA SA, 2019-08-13)
    We describe the genetic diversity of 1327 Brucella strains from human patients in Kazakhstan using multiple-locus variable-number tandem repeat (VNTR) analysis (MLVA). All strains were assigned to the Brucella melitensis ...

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