The mammalian legumain, also called asparaginyl endopeptidase
(AEP), is critically involved in the processing
of bacterial antigens for MHC class II presentation.
In order to investigate the substrate specificity
of ...
The prognosis of lymphoid neoplasms has improved considerably during the last decades. However, treatment response for some lymphoid neoplasms is still poor, indicating the need for new therapeutic approaches. One promising ...
Major histocompatibility complex (MHC) class I molecules present antigenic
peptides to cytotoxic T cells. During an adaptive immune response, MHC molecules are
regulated by several mechanisms including lipopolysaccharide ...
Mostafa, Haouraa; Pala, Andrej; Högel, Josef; Hlavac, Michal; Dietrich, Elvira; Westhoff, M. Andrew; Nonnenmacher, Lisa; Burster, Timo; Georgieff, Michael; Wirtz, C. Rainer; Schneider, E. Marion(Journal of Hematology and Oncology, 2016-09-01)
Background: Glioblastoma multiforme (GBM), a common primary malignant brain tumor, rarely disseminates beyond
the central nervous system and has a very bad prognosis. The current study aimed at the analysis of ...
Protease-mediated degradation of proteins is critical in a plethora of physiological processes.
Neutrophils secrete serine proteases including cathepsin G (CatG), neutrophile
elastase (NE), and proteinase 3 (PR3) together ...
Autoantigenic peptides resulting from self-proteins such as proinsulin are important players in the development of type 1
diabetes mellitus (T1D). Self-proteins can be processed by cathepsins (Cats) within endocytic ...
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