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Base Metal Catalysts for Deoxygenative Reduction of Amides to Amines

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dc.contributor.author Khalimon, Andrey
dc.contributor.author Gudun, Kristina
dc.contributor.author Hayrapetyan, Davit
dc.date.accessioned 2019-11-05T11:41:25Z
dc.date.available 2019-11-05T11:41:25Z
dc.date.issued 2019-06-01
dc.identifier.citation Khalimon, A., Gudun, K. A., & Hayrapetyan, D. (2019). Base metal catalysts for deoxygenative reduction of amides to amines. Catalysts, 9(6), [490]. https://doi.org/10.3390/catal9060490 en_US
dc.identifier.uri https://doi.org/10.3390/catal9060490
dc.identifier.uri http://nur.nu.edu.kz/handle/123456789/4294
dc.description.abstract The development of efficient methodologies for production of amines attracts significant attention from synthetic chemists, because amines serve as essential building blocks in the synthesis of many pharmaceuticals, natural products, and agrochemicals. In this regard, deoxygenative reduction of amides to amines by means of transition-metal-catalyzed hydrogenation, hydrosilylation, and hydroboration reactions represents an attractive alternative to conventional wasteful techniques based on stoichiometric reductions of the corresponding amides and imines, and reductive amination of aldehydes with metal hydride reagents. The relatively low electrophilicity of the amide carbonyl group makes this transformation more challenging compared to reduction of other carbonyl compounds, and the majority of the reported catalytic systems employ precious metals such as platinum, rhodium, iridium, and ruthenium. Despite the application of more abundant and environmentally benign base metal (Mn, Fe, Co, and Ni) complexes for deoxygenative reduction of amides have been developed to a lesser extent, such catalytic systems are of great importance. This review is focused on the current achievements in the base-metal-catalyzed deoxygenative hydrogenation, hydrosilylation, and hydroboration of amides to amines. Special attention is paid to the design of base metal catalysts and the mechanisms of such catalytic transformations en_US
dc.language.iso en en_US
dc.publisher Nazarbayev University School of Sciences and Humanities en_US
dc.rights Attribution-NonCommercial-ShareAlike 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/us/ *
dc.title Base Metal Catalysts for Deoxygenative Reduction of Amides to Amines en_US
dc.type Article en_US
workflow.import.source science

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