New arthritic pannus-specific protein promotes fibroblast motility and polarization

dc.contributor.author	Adilbayeva, A.
dc.contributor.author	Myngbay, A.
dc.contributor.author	Adarichev, V. A.
dc.date.accessioned	2015-10-21T09:42:29Z
dc.date.available	2015-10-21T09:42:29Z
dc.date.issued	2014
dc.identifier.uri	http://nur.nu.edu.kz/handle/123456789/416
dc.description.abstract	Rheumatoid arthritis (RA) is chronic inflammatory disease characterized by the development of hypercellular pannus tissue in the affected joints of patients. Pannus invasiveness and activation correlates with stronger tissue destruction and worse clinical prognosis. Using murine arthritis model, we recently discovered that synovial concentration of Collagen Triple Helix Repeat-containing 1 (CTHRC1) message and protein is directly correlated with arthritis severity. In carcinogenesis, overexpression of CTHRC1 is associated with enhanced metastatic potential of solid tumors and increased cell motility. Our goal is to investigate the mechanism of synovial cell motility and invasiveness and the role of non-canonical WNT signaling in pannus development.	ru_RU
dc.language.iso	en	ru_RU
dc.publisher	Nazarbayev University	ru_RU
dc.subject	fibroblast motility	ru_RU
dc.subject	protein	ru_RU
dc.subject	cell morphology	ru_RU
dc.subject	cell movement velocity	ru_RU
dc.subject	cell polarization	ru_RU
dc.title	New arthritic pannus-specific protein promotes fibroblast motility and polarization	ru_RU
dc.type	Abstract	ru_RU