Gene expression and methylation profiles as a biomarker for human radiation exposure

Abstract

Taking into account the fact that Kazakhstan is one of the world's leaders in uranium mining, and given the extent of the damage suffered as a result of the work on the Semipalatinsk nuclear test site, the general background radiation in some regions came under the influence of additional effects of chronic exposure to low doses of radiation, the study and search for new methods of dosimetry, as an integral part of the radiological protection of the population, is a priority for the state. The purpose of this study is the search for and development of potential biomarkers by assessing the impact if ionising radiation on gene expression and quantification of global methylation and hydroxymethylation of uranium industry workers.